McInnes Colin W, Reynolds Richard Ak, Arneja Jugpal S
Faculty of Medicine, University of British Columbia, Vancouver, British Columbia;
Can J Plast Surg. 2011 Summer;19(2):60-1.
Heterotopic ossification (HO) is a process whereby lamellar bone forms in the soft tissues surrounding a joint. The most common type of HO is traumatic myositis ossificans, which develops following traumatic injuries, burns or arthroplasty. A variety of other forms of HO also exist, such as those associated with central nervous system injury and systemic forms that can manifest at other joints simultaneously. Clinically, patients can present with decreased range of motion, pressure ulcers, nerve compression, swelling, pain or asymptomatically. Symptomatic patients are most commonly treated with surgical debridement of the affected heterotopic deposits.Spinal dysraphism (SD) is a term describing a wide range of congenital malformations of the neural tube, ranging from spina bifida occulta to the more severe form, myelomeningocele. The cause of SD is multifactorial and has been associated with chromosomal disorders, teratogenic exposure and folate deficiency. Many patients with SD experience neuropathy below the affected neurological level, making them particularly susceptible to pressure ulcers. If these ulcers are severe and do not respond to conservative therapy, they often require surgical debridement and flap reconstruction - a clinical scenario that rarely results in HO.The present article describes a case involving a patient with pelvic HO following myocutaneous flap reconstruction of a pressure ulcer. The patient was successfully treated with oral bisphosphonate and aggressive physiotherapy.
异位骨化(HO)是一种在关节周围软组织中形成板层骨的过程。最常见的HO类型是创伤性骨化性肌炎,它在创伤性损伤、烧伤或关节置换术后发生。还存在多种其他形式的HO,例如与中枢神经系统损伤相关的类型以及可同时在其他关节表现出来的全身性形式。临床上,患者可能出现活动范围减小、压疮、神经受压、肿胀、疼痛或无症状。有症状的患者最常采用手术切除受影响的异位沉积物进行治疗。脊柱裂(SD)是一个术语,描述了从隐性脊柱裂到更严重形式的脊髓脊膜膨出等广泛的神经管先天性畸形。SD的病因是多因素的,并且与染色体疾病、致畸物暴露和叶酸缺乏有关。许多SD患者在受影响的神经水平以下会出现神经病变,这使他们特别容易发生压疮。如果这些溃疡严重且对保守治疗无反应,它们通常需要手术清创和皮瓣重建——这种临床情况很少导致HO。本文描述了一例在压疮肌皮瓣重建后发生盆腔HO的患者。该患者通过口服双膦酸盐和积极的物理治疗成功治愈。