新生儿惊厥：临床与基础的对话。

Neonatal seizures: dialogues between clinic and bench.

机构信息

Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao Sung, Kaohsiung 833, Taiwan.

出版信息

J Formos Med Assoc. 2012 May;111(5):239-44. doi: 10.1016/j.jfma.2011.12.007. Epub 2012 Apr 7.

DOI:10.1016/j.jfma.2011.12.007

PMID:22656393

Abstract

Neonatal seizures are common and often reflect a severe underlying neurologic dysfunction in neonates. Phenobarbital remains the mainstay of treatment of neonatal seizures, however, but it is ineffective in many patients and has adverse profiles in cognition. Furthermore, gamma-aminobutyric acid is excitatory early in brain development; therefore, treatment of neonatal seizures with phenobarbital must be cautious. In this review, we highlight the substantial progress that has been made in animal studies, and translate these results to the treatment of seizures in human neonates.

摘要

新生儿癫痫发作很常见，通常反映出新生儿严重的潜在神经功能障碍。苯巴比妥仍然是新生儿癫痫发作的主要治疗方法，然而，它在许多患者中无效，并且在认知方面有不良影响。此外，γ-氨基丁酸在大脑发育早期是兴奋性的；因此，用苯巴比妥治疗新生儿癫痫发作必须谨慎。在这篇综述中，我们强调了在动物研究中取得的重大进展，并将这些结果转化为人类新生儿癫痫发作的治疗。