Cardiology Division, New York Medical College, USA.
Arch Med Sci. 2012 May 9;8(2):375-88. doi: 10.5114/aoms.2012.28568.
Persons with peripheral arterial disease (PAD) are at increased risk for all-cause mortality, cardiovascular mortality, and mortality from coronary artery disease. Smoking should be stopped and hypertension, dyslipidemia, diabetes mellitus, and hypothyroidism treated. Statins reduce the incidence of intermittent claudication and improve exercise duration until the onset of intermittent claudication in persons with PAD and hypercholesterolemia. The serum low-density lipoprotein cholesterol should be reduced to < 70 mg/dl. Antiplatelet drugs such as aspirin or clopidogrel, angiotensin-converting enzyme inhibitors, and statins should be given to persons with PAD. β-Blockers should be given if coronary artery disease is present. Cilostazol improves exercise time until intermittent claudication. Exercise rehabilitation programs should be used. Revascularization should be performed if indicated.
外周动脉疾病（PAD）患者的全因死亡率、心血管死亡率和冠心病死亡率均升高。应戒烟，并治疗高血压、血脂异常、糖尿病和甲状腺功能减退。他汀类药物可降低间歇性跛行的发生率，并改善有 PAD 和高胆固醇血症患者的跛行发作前的运动时间。应将血清低密度脂蛋白胆固醇降至<70mg/dl。应给予 PAD 患者抗血小板药物如阿司匹林或氯吡格雷、血管紧张素转换酶抑制剂和他汀类药物。如果存在冠状动脉疾病，应给予β受体阻滞剂。西洛他唑可改善间歇性跛行发作前的运动时间。应使用运动康复计划。如果有指征，应进行血运重建。
