Nakajima K, Fotouhi F, Taki J, Ohno T, Taniguchi M, Bunko H, Hisada K
Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan.
Nucl Med Commun. 1990 Oct;11(10):677-84. doi: 10.1097/00006231-199010000-00003.
To estimate right ventricular overload in paediatric cardiac disease, 201Tl scintigraphy was used to quantify right ventricular uptake. Six methods for calculating the 201Tl right-to-left ventricular uptake ratio (TRL) were compared, based on the location of regions of interest (ROIs), use of total count or mean count density, and the ROI-based method or profile method. When the TRL was compared with the right-to-left ventricular peak systolic pressure ratio (RVP/LVP), the mean count density method using entire right and left ventricular ROIs seemed to be appropriate, considering its simplicity, reproducibility and regression line. The linear regression line was RVP/LVP = 1.15 x TRL - 0.13 (n = 15, P = -0.0001), and RVP(mm Hg) = 162 x TRL - 33 (n = 15, P = 0.0001). In four patients with pulmonary stenosis, the changes of TRL were in good agreement with the right ventricular pressure changes after percutaneous balloon valvuloplasty. Thus, evaluation of thallium scintigraphy using this quantitative method can be a simple and effective way to evaluate patients with right ventricular pressure overloading.
为评估小儿心脏疾病中的右心室负荷过重情况，采用铊-201闪烁显像术对右心室摄取进行定量分析。基于感兴趣区（ROI）的位置、使用总计数或平均计数密度以及基于ROI的方法或轮廓法，比较了六种计算铊-201右心室与左心室摄取比（TRL）的方法。当将TRL与右心室与左心室收缩压峰值比（RVP/LVP）进行比较时，考虑到其简单性、可重复性和回归线，使用整个右心室和左心室ROI的平均计数密度法似乎较为合适。线性回归线为RVP/LVP = 1.15×TRL - 0.13（n = 15，P = -0.0001），以及RVP（mmHg） = 162×TRL - 33（n = 15，P = 0.0001）。在4例肺动脉狭窄患者中，TRL的变化与经皮球囊瓣膜成形术后右心室压力变化高度一致。因此，使用这种定量方法进行铊闪烁显像评估可以成为评估右心室压力过载患者的一种简单有效的方法。
