Evolution of the cadherin-catenin complex.

Adherens junctions are the most common junction type found in animal epithelia. Their core components are classical cadherins and catenins, which form membrane-spanning complexes that mediate intercellular binding on the extracellular side and associate with the actin cytoskeleton on the intracellular side. Junctional cadherin-catenin complexes are key elements involved in driving animal morphogenesis. Despite their ubiquity and importance, comparative studies of classical cadherins, catenins and their related molecules suggest that the cadherin/catenin-based adherens junctions have undergone structural and compositional transitions during the diversification of animal lineages. This chapter describes the molecular diversities related to the cadherin-catenin complex, based on accumulated molecular and genomic information. Understanding when and how the junctional cadherin-catenin complex originated, and its subsequent diversification in animals, promotes a comprehensive understanding of the mechanisms of animal morphological diversification.