Laboratory of Neuroimmunology School of Psychology, University of Newcastle, Building W, University Drive, Callaghan, NSW 2308, Australia.
Dev Psychobiol. 2012 Jul;54(5):568-75. doi: 10.1002/dev.20615. Epub 2011 Oct 17.
The current study investigated the effects of neonatal infection with Chlamydia muridarum bacteria on glucocorticoid (GR) and mineralocorticoid (MR) receptors in the adult mouse hippocampus. In male adults infected at birth, circulating corticosterone was significantly increased when compared to same sex controls; while neonatal infection resulted in female adults with significantly increased GR mRNA compared to same sex controls. When comparing males and females after neonatal infection, males had significantly less GR protein than females. Interestingly, after control treatment, males had significantly more GR mRNA, MR mRNA, and GR protein with significantly lower corticosterone than females. Neonatal respiratory infection significantly impacts adult hippocampal GR and MR, and circulating corticosterone in a sex-specific manner potentially altering stress responsivity.
本研究调查了新生期感染鼠衣原体对成年小鼠海马糖皮质激素（GR）和盐皮质激素（MR）受体的影响。与同性别对照组相比，出生时感染的雄性成年动物的循环皮质酮显著增加；而新生期感染导致雌性成年动物的 GR mRNA 显著高于同性别对照组。在比较新生期感染后的雄性和雌性后，雄性的 GR 蛋白明显少于雌性。有趣的是，经过对照处理后，雄性的 GR mRNA、MR mRNA 和 GR 蛋白显著增加，而皮质酮显著低于雌性。新生期呼吸道感染以性别特异性的方式显著影响成年海马 GR 和 MR 以及循环皮质酮，可能改变应激反应性。
