Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Biofactors. 2012 Sep-Oct;38(5):338-48. doi: 10.1002/biof.1031. Epub 2012 Jun 7.
The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common protein-protein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found in most cell types, but neuronal proteins, for example, are particularly rich in these domains. The general function of PDZ domains is to bring proteins together within the appropriate cellular compartment, thereby facilitating scaffolding, signaling, and trafficking events. The many functions of PDZ domains under normal physiological as well as pathological conditions have been reviewed recently. In this review, we focus on the molecular details of how PDZ domains bind their protein ligands and their potential as drug targets in this context.
突触后密度蛋白-95/盘状结构域/紧密连接蛋白-1（PDZ）蛋白结构域家族是哺乳动物细胞中最常见的蛋白-蛋白相互作用模块之一，在几百个人类蛋白中都存在其同源物。PDZ 结构域存在于大多数细胞类型中，但神经元蛋白尤其富含这些结构域。PDZ 结构域的一般功能是将蛋白质聚集在适当的细胞隔室中，从而促进支架、信号和运输事件。PDZ 结构域在正常生理和病理条件下的许多功能最近已经被综述过。在这篇综述中，我们重点介绍 PDZ 结构域结合其蛋白配体的分子细节，以及在这种情况下它们作为药物靶点的潜力。
