Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Republic of Korea.
Med Hypotheses. 2012 Aug;79(2):202-3. doi: 10.1016/j.mehy.2012.04.035. Epub 2012 Jun 9.
The pathogenesis of sudden sensorineural hearing loss (SSNHL) is unclear, though some researchers postulate the major mechanism of onset to be via circulatory disturbance or cochlear inflammation. SSNHL can represent the sole manifestation of anterior inferior cerebellar artery infarction, and patients with a SSNHL may have higher than normal risk of future stoke. According to a vascular remodeling theory, vertebral arteries (VAs) are typically asymmetric with the basilar artery (BA) gradually curving in the opposite direction of the larger VA. Decreased wall shear stress on the inner surface of the curvature (weaker side of the vertebral artery) gives rise to an atherothrombogenic environment. It is hypothesized that angulation of the BA could contribute to the decline of anterior inferior cerebellar artery (AICA) flow or to the development of atheroma formation in the AICA orifice. Vertebrobasilar junction angulation could represent a simple and useful marker of SSNHL caused by a vascular compromise of the cochlea.
突发性聋（SSNHL）的发病机制尚不清楚，尽管一些研究人员推测其主要发病机制是通过循环障碍或耳蜗炎症。SSNHL 可表现为小脑前下动脉梗死的唯一表现，且 SSNHL 患者未来发生中风的风险高于正常水平。根据血管重塑理论，椎动脉（VA）通常不对称，基底动脉（BA）逐渐向较大 VA 的相反方向弯曲。曲率内表面（椎动脉较弱侧）的壁面切应力降低会导致动脉粥样血栓形成环境。据推测，BA 的成角可能导致小脑前下动脉（AICA）血流下降，或者 AICA 口形成动脉粥样硬化。椎基底动脉交界处的成角可能是耳蜗血管损伤导致 SSNHL 的一个简单而有用的标志物。
