库欣病和肢端肥大症患者血清褪黑素的昼夜节律特征。

Circadian profile of serum melatonin in Cushing's disease and acromegaly.

作者信息

Piovesan A, Terzolo M, Borretta G, Torta M, Buniva T, Osella G, Paccotti P, Angeli A

机构信息

Dipartimento di Scienze Cliniche e Biologiche, Università di Torini, Italy.

出版信息

Chronobiol Int. 1990;7(3):259-61. doi: 10.3109/07420529009056984.

DOI:10.3109/07420529009056984

PMID:2268888

Abstract

We evaluated the circadian profiles of serum melatonin (MT) and cortisol in 6 patients with Cushing's disease while those of serum MT and GH were evaluated in 8 patients with acromegaly. The control group consisted of 15 healthy subjects in whom MT, cortisol and GH were determined. The presence of a circadian rhythmicity was validated by the cosinor method, while the diurnal and nocturnal amount of MT secretion were expressed in terms of area under the curve. Gross alterations of MT rhythm were not apparent in Cushing's patients. In acromegalics, we observed a blunted day-night oscillation of MT accounted for by a significant increase of its secretion during the day-time period.

摘要

我们评估了6例库欣病患者血清褪黑素（MT）和皮质醇的昼夜节律，同时评估了8例肢端肥大症患者血清MT和生长激素（GH）的昼夜节律。对照组由15名健康受试者组成，测定了他们的MT、皮质醇和GH。通过余弦分析法验证昼夜节律的存在，而MT分泌的昼夜量则用曲线下面积表示。库欣病患者MT节律的明显改变并不明显。在肢端肥大症患者中，我们观察到MT的昼夜振荡减弱，这是由于白天其分泌显著增加所致。