一种用于治疗性一氧化碳递送的肽基材料。
A Peptide-Based Material for Therapeutic Carbon Monoxide Delivery.
作者信息
Matson John B, Webber Matthew J, Tamboli Vibha K, Weber Benjamin, Stupp Samuel I
机构信息
Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL, 60611, USA. ; Tel: (+312) 503-6713.
出版信息
Soft Matter. 2012 Jan 1;8(25):2689-2692. doi: 10.1039/C2SM25785H. Epub 2012 May 24.
Abstract
We report on the preparation of the first material for therapeutic delivery of CO. A peptide amphiphile was synthesized with a covalently attached ruthenium tricarbonyl. Self-assembled nanofiber gels containing this peptide spontaneously released CO with prolonged release kinetics compared to soluble CO donors. Oxidatively stressed cardiomyocytes had improved viability when treated with this peptide, demonstrating its potential as a biodegradable gel for localized therapeutic CO delivery.
摘要
我们报道了首个用于一氧化碳治疗性递送的材料的制备。合成了一种共价连接有三羰基钌的肽两亲分子。与可溶性一氧化碳供体相比，含有这种肽的自组装纳米纤维凝胶能自发释放一氧化碳，且释放动力学呈延长趋势。用这种肽处理氧化应激的心肌细胞后，细胞活力得到改善，这表明其作为用于局部治疗性一氧化碳递送的可生物降解凝胶具有潜力。
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