循环疗法：开启癌症治疗的治疗窗口。
Cyclotherapy: opening a therapeutic window in cancer treatment.
作者信息
van Leeuwen Ingeborg M M
机构信息
Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
出版信息
Oncotarget. 2012 Jun;3(6):596-600. doi: 10.18632/oncotarget.524.
Abstract
Cyclotherapy is a promising endeavor to improve cancer treatment by tackling the dose-limiting side effects of chemotherapy, especially for cancers harboring mutations in the TP53 tumor suppressor. In this particular context, pretreatment with a p53 activator halts proliferation in healthy tissue, while leaving the p53-deficient tumor susceptible to conventional chemotherapy.
摘要
循环疗法是一项很有前景的尝试，旨在通过解决化疗的剂量限制性副作用来改善癌症治疗，特别是对于那些在TP53肿瘤抑制基因中存在突变的癌症。在这种特定情况下，用p53激活剂进行预处理可使健康组织中的细胞增殖停止，而使缺乏p53的肿瘤对传统化疗敏感。
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