Blin O, Durup M, Pailhous J, Serratrice G
Clinique des Maladies du Systeme Nerveux et de l'Appareil Locomoteur, CHU Timone, Marseille, France.
Clin Neuropharmacol. 1990 Oct;13(5):426-35. doi: 10.1097/00002826-199010000-00004.
Apomorphine (10 micrograms/kg subcutaneously with oral domperidone 10 mg), oral sultopride (50 mg), and placebos were given to nine normal volunteers, using a Latin-square design and double-blind procedures. A battery of tests was applied before the dose, and after the dose after time lapses of 15, 45, 90, 105, 120, and 180 min. Spatiotemporal and dynamic gait parameters, gait stability, and modulations remained unchanged with all three treatments. Apomorphine induced repeated yawning in all subjects. Akathisia was observed in four of nine subjects with sultopride. Sultopride was associated with drowsiness and sleepiness on visual analog scales. Akathisia may be related to decreased dopaminergic activity in the prefrontal cortex and mesocortical dopamine system blockade. The imbalance between mesocortical and nigrostriatal dopaminergic systems might explain the fact that sultopride in our experiment modified spontaneous behavior but not volitional behavior. Thus, it is possible to discriminate between two types of increased motor activity, and motility must be distinguished from locomotor activity.
采用拉丁方设计和双盲程序，给9名正常志愿者皮下注射阿扑吗啡（10微克/千克）并口服多潘立酮10毫克、口服舒托必利（50毫克）以及安慰剂。在给药前、给药后15、45、90、105、120和180分钟后进行一系列测试。三种治疗方法对时空和动态步态参数、步态稳定性及调节均无影响。阿扑吗啡使所有受试者反复打哈欠。9名服用舒托必利的受试者中有4人出现静坐不能。舒托必利在视觉模拟量表上与嗜睡和困倦有关。静坐不能可能与前额叶皮质多巴胺能活性降低及中皮质多巴胺系统阻断有关。中皮质和黑质纹状体多巴胺能系统之间的失衡可能解释了我们实验中舒托必利改变自发行为而非意志行为这一现象。因此，有可能区分两种类型的运动活动增加，并且必须将能动性与运动活动区分开来。
