Department of Otolaryngology-Head & Neck Surgery, Washington University School of Medicine, St Louis, MO, USA.
Otolaryngol Head Neck Surg. 2012 Nov;147(5):900-6. doi: 10.1177/0194599812451414. Epub 2012 Jun 21.
To assess functional connectivity in cortical networks in patients with nonbothersome tinnitus compared with a normal healthy nontinnitus control group by measuring low-frequency (<0.1 Hz) spontaneous blood oxygenation level-dependent (BOLD) signals at rest.
Case-control.
Academic medical center.
Nonbothersome, idiopathic subjective tinnitus for at least 6 months (n = 18) and a normal healthy nontinnitus control group (n = 23).
Functional connectivity differences in 58 a priori selected seed regions of interest encompassing cortical loci in the default mode, attention, auditory, visual, somatosensory, and cognitive networks.
The median age of the 18 subjects was 54 years (interquartile range [IQR], 52-57), 66% were male, 90% were white, median Tinnitus Handicap Inventory (THI) score was 8 (IQR, 4-14), and a median Beck Depression Index score was 1 (IQR, 0-5). The median age for the control group was 46 years (IQR, 39-54), and 52% were male. Of the 58 seeds analyzed, no regions had significantly different functional connectivity among the nonbothersome tinnitus group when compared with the control group.
Among nonbothersome tinnitus patients, the tinnitus percept does not appear to alter the functional connectivity of the auditory cortex or other key cortical regions. Trial Registration ClinicalTrials.gov Identifier: NCT01049828.
通过测量静息状态下低频（<0.1 Hz）自发血氧水平依赖（BOLD）信号，评估无困扰性耳鸣患者与正常健康无耳鸣对照组之间皮质网络的功能连接。
病例对照研究。
学术医疗中心。
至少有 6 个月无困扰性、特发性主观性耳鸣的患者（n = 18）和正常健康无耳鸣对照组（n = 23）。
包括默认模式、注意力、听觉、视觉、躯体感觉和认知网络在内的皮质部位的 58 个预设种子区域的功能连接差异。
18 名受试者的中位年龄为 54 岁（四分位距 [IQR]，52-57），66%为男性，90%为白人，中位耳鸣残疾量表（THI）评分为 8（IQR，4-14），贝克抑郁指数中位数为 1（IQR，0-5）。对照组的中位年龄为 46 岁（IQR，39-54），52%为男性。在分析的 58 个种子中，无困扰性耳鸣组与对照组之间没有明显的功能连接差异。
在无困扰性耳鸣患者中，耳鸣感知似乎不会改变听觉皮层或其他关键皮质区域的功能连接。
ClinicalTrials.gov 标识符：NCT01049828。
