姜黄素在可见光下对 HeLa 细胞具有显著的光细胞毒性，并能阻止其在形成氧钒(IV)配合物时的降解。

Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(IV) complex formation.

机构信息

Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India.

出版信息

Chem Commun (Camb). 2012 Aug 11;48(62):7702-4. doi: 10.1039/c2cc33576j. Epub 2012 Jun 29.

Abstract

Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells in visible light of 400-700 nm giving IC(50) = 8.2 ± 0.2 μM and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex [VO(cur)(dppz)Cl] (IC(50) = 3.3 ± 0.4 μM), while both are less toxic in the dark.

摘要

姜黄素（Hcur）作为一种细胞成像和 PDT 试剂，在 400-700nm 的可见光下对 HeLa 细胞显示出显著的光细胞毒性，IC50 为 8.2±0.2μM，其降解在形成光细胞毒性二吡啶并吩嗪（dppz）络合物[VO（cur）（dppz）Cl]（IC50 为 3.3±0.4μM）时被阻止，而在黑暗中两者的毒性都较低。