CEA, Institut de Biologie et Technologies de Saclay, Gif-sur-Yvette, France.
Nat Prod Rep. 2012 Sep;29(9):961-79. doi: 10.1039/c2np20010d. Epub 2012 Jul 3.
We review here work on the biosynthesis of diketopiperazines (DKPs), a large class of natural products with noteworthy biological activities, focusing on the biosynthetic pathways involving cyclodipeptide synthases (CDPSs), a newly defined family of enzymes. Distinct from nonribosomal peptide synthetases (NRPSs), the other family of enzymes synthesizing DKPs, CDPSs bridge the primary and secondary metabolic pathways by hijacking aminoacyl-tRNAs to produce DKPs. This review includes a comprehensive description of the state of the art for CDPS-dependent pathways, and highlights the ways in which this knowledge could be used to increase the diversity of natural DKPs by pathway engineering.
我们在此回顾了二酮哌嗪（DKP）的生物合成研究，这是一类具有显著生物活性的天然产物，重点介绍了涉及环二肽合酶（CDPS）的生物合成途径，CDPS 是一个新定义的酶家族。与非核糖体肽合酶（NRPSs）不同，NRPSs 是另一种合成 DKP 的酶家族，CDPS 通过劫持氨酰-tRNA 来产生 DKP，从而连接初级和次级代谢途径。本综述全面描述了 CDPS 依赖途径的最新技术状态，并强调了如何通过途径工程来增加天然 DKP 的多样性。
