Department of Radiology, Stavanger University Hospital, Stavanger, Norway.
Cardiovasc Intervent Radiol. 2012 Oct;35(5):1029-35. doi: 10.1007/s00270-012-0438-5. Epub 2012 Jun 30.
To evaluate the safety and efficacy of neurointerventional procedures in acute stroke patients performed by a team of vascular interventional radiologists in close cooperation with diagnostic neuroradiologists and stroke neurologists and to compare the results with those of previous reports from centres with specialised interventional neuroradiologists.
A total of 39 patients with acute ischemic stroke due to large-vessel occlusion not responding to or not eligible for intravenous thrombolysis were treated with either intra-arterial thrombolysis or mechanical thrombectomy (Penumbra System or solitaire FR thrombectomy system, respectively) and included in our prospective study. Outcomes were measured using the modified Rankin scale after 90 days, and recanalization was assessed by thrombolysis using the myocardial infarction score.
Mean patient age was 68.3 ± 14.2 years; the average National Institutes of Health Stroke Scale score at hospital admission was 17.2 (SD = 6.2 [n = 38]). Successful recanalization was achieved in 74.4 % of patients. Median time from clinical onset to recanalization was 5 h 11 min. Procedure-related complications occurred in 5 % of patients, and 7.5 % had a symptomatic intracerebral hemorrhage. Of the patients, 22.5 % died within the first 90 postprocedural days, 5 % of these from cerebral causes. Patients who were successfully recanalized had a clinical better outcome at follow-up than those in whom treatment failed. Of the patients, 35.9 % had an mRS score ≤2 after 90 days.
Our results are in line with those in the published literature and show that a treatment strategy with general interventional radiologists performing neurointerventional procedures in acute stroke patients with large vessel occlusions can be achieved to the benefit of patients.
评估由血管介入放射学家与诊断神经放射学家和卒中神经科医生密切合作的团队进行的急性卒中患者神经介入手术的安全性和疗效,并将结果与具有专业神经介入放射学家的中心的以往报告进行比较。
共纳入 39 例因大血管闭塞且对静脉溶栓无反应或不适合静脉溶栓的急性缺血性卒中患者,分别采用动脉内溶栓或机械血栓切除术(分别为 Penumbra 系统或 solitaire FR 血栓切除术系统)进行治疗,并纳入我们的前瞻性研究。使用改良 Rankin 量表在 90 天后测量结局,通过心肌梗死评分评估溶栓的再通情况。
患者平均年龄为 68.3 ± 14.2 岁;入院时平均国立卫生研究院卒中量表评分 17.2(SD = 6.2 [n = 38])。74.4%的患者成功再通。从临床发病到再通的中位数时间为 5 小时 11 分钟。5%的患者发生与操作相关的并发症,7.5%发生症状性颅内出血。在最初 90 天内,22.5%的患者死亡,其中 5%死于脑原因。在随访中,成功再通的患者临床结局优于治疗失败的患者。90 天后,35.9%的患者 mRS 评分≤2。
我们的结果与已发表的文献一致,表明具有一般介入放射学医生的治疗策略在急性大血管闭塞卒中患者中进行神经介入手术可以使患者受益。