Staritz M
I. Medizinische Klinik und Poliklinik der Universität Mainz.
Z Gastroenterol. 1990 Aug;28(8):405-7.
Haemorrhage from oesophageal varices is still a life-threatening complication of portal hypertension. Parameters which are suitable to identify patients being at risk to bleed are urgently required to decide which patients should be candidates for prophylactic therapy. Recent studies showed that only 18% of bleeders present with small, however 49.9% with large varices. 80% had red color sign of the variceal wall and significantly higher intravariceal hydrostatic pressure (21.9 mmHg vs 14.7 mmHg, p less than 0.001) than patients without previous haemorrhage. Advanced liver disease (Child's C) is an additional risk factor. However, the clinical value of the endoscopic parameters is limited by a significant overlap of variceal size and pressure obtained in bleeders and non-bleeders. Thus, only patients with small varices, (Grade I), low variceal pressure (below 12 mmHg), and fair condition are unlikely to develop variceal bleeding. A significant additional clinical value of the parameters is provided by the fact that they allow accurate definition of patients with portal hypertension particularly for further clinical studies.
食管静脉曲张出血仍然是门静脉高压症危及生命的并发症。迫切需要一些合适的参数来识别有出血风险的患者,以决定哪些患者应作为预防性治疗的候选对象。最近的研究表明,只有18%的出血者静脉曲张较小,而49.9%的出血者静脉曲张较大。80%的出血者静脉曲张壁有红色征,且其静脉曲张内静水压(21.9 mmHg对14.7 mmHg,p<0.001)明显高于既往无出血的患者。晚期肝病(Child's C级)是另一个危险因素。然而,内镜参数的临床价值受到出血者和未出血者静脉曲张大小和压力存在显著重叠的限制。因此,只有静脉曲张较小(I级)、静脉曲张压力较低(低于12 mmHg)且病情尚可的患者不太可能发生静脉曲张出血。这些参数具有显著的额外临床价值,因为它们能够准确界定门静脉高压症患者,尤其适用于进一步的临床研究。