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天津第一中心医院肝脏移植项目

The Liver Transplant Program at Tianjin First Center Hospital.

作者信息

Shen Zhongyang

机构信息

Tianjin First Center Hospital, Nan Kai District, Tianjin, PR China.

出版信息

Clin Transpl. 2011:203-11.

Abstract

The liver transplant program at the transplant center of Tianjin First Center Hospital opened in 1994 and has become a leading center for academic research and development in clinical liver transplantation during the past 18 years. As of Nov 30, 2011, we had performed 4,103 liver transplantations in patients ranging from 6 months to 79 years old. Since 1998, the program has ranked first in mainland China in the annual number of liver transplants performed, the cumulative total liver transplants and the number of long-surviving patients. We've accomplished a number of "firsts" among the Chinese liver transplant centers, including: the first split liver transplantation, the first pediatric liver transplant, the first living donor simultaneous liver-kidney transplant, the first dual-graft liver transplant using a domino right lobe and a living donor left lobe, the first laparoscopic assisted live donor right hepatectomy including the middle hepatic vein and we have assembled the first liver transplant chain comprising multiple donors and recipients. We have performed the largest number of living related and split liver transplantations in mainland China. The combined prophylactic protocol of "Lamivudine and HBIG" to prevent HBV recurrence post transplantation was first used by our center in China and now is utilized by most of the domestic transplant centers. We have begun using livers from donors after cardiac death (DCD) during the past 2 years, with careful donor selection and recipient management. All the approaches and techniques we've developed are aimed at the utilization of all types of available grafts. However, increasing the rate of transplantation with excellent graft and recipient survival are still the challenges facing us.

摘要

天津第一中心医院移植中心的肝移植项目始于1994年,在过去18年里已成为临床肝移植学术研究与发展的领先中心。截至2011年11月30日,我们已为年龄从6个月至79岁的患者实施了4103例肝移植手术。自1998年以来,该项目在中国大陆的肝移植年手术量、累计肝移植总量以及长期存活患者数量方面均排名第一。我们在中国肝移植中心中创造了多项“首例”,包括:首例劈离式肝移植、首例小儿肝移植、首例活体供肝肝肾联合移植、首例使用多米诺右半肝和活体供肝左半肝的双供肝肝移植、首例保留肝中静脉的腹腔镜辅助活体供肝右半肝切除术,并且组建了首个由多个供体和受体组成的肝移植链。我们在中国大陆实施的亲属活体肝移植和劈离式肝移植数量最多。我院率先在国内采用“拉米夫定联合乙肝免疫球蛋白”的联合预防方案预防移植后乙肝复发,目前该方案已被国内大多数移植中心采用。在过去两年里,我们开始使用心脏死亡后供体(DCD)的肝脏,并对供体进行仔细筛选和受体管理。我们所开发的所有方法和技术均旨在利用各种可用的移植物。然而,提高移植成功率并使移植物和受体获得良好存活仍然是我们面临的挑战。

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