了解肾移植患者中低水平预先形成的供体特异性抗HLA抗体的意义。

Understanding the significance of low-level preformed donor-specific anti-HLA antibodies in renal transplant patients.

作者信息

Wu Pingping, Everly Matthew J, Jin Juan, Mao Youying, Chen Jianghua

机构信息

The Kidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.

出版信息

Clin Transpl. 2011:365-8.

PMID:22755432

Abstract

This is a single center, retrospective cohort study showing the impact of pre-transplant HLA-DSA (detected by the SAFB) on early posttransplant rejection rates. Our results showed that low level pretransplant DSA detected by SAFB is associated with a high risk of early clinical AMR. However, not all patients with pretransplant DSA will go on to develop AMR. Post-transplant with a decrease/removal of DSA within one month will lead to a low rate of AMR. Conversely, those who have a high DSA MFI are at the highest risk of early AMR. These findings support using SAFB for pretransplant assessment and early posttransplant monitoring.

摘要

这是一项单中心回顾性队列研究，展示了移植前HLA-DSA（通过SAFB检测）对移植后早期排斥反应发生率的影响。我们的结果表明，通过SAFB检测到的低水平移植前DSA与早期临床急性抗体介导排斥反应的高风险相关。然而，并非所有移植前有DSA的患者都会发生急性抗体介导排斥反应。移植后一个月内DSA降低/清除的患者急性抗体介导排斥反应发生率较低。相反，那些DSA平均荧光强度较高的患者发生早期急性抗体介导排斥反应的风险最高。这些发现支持将SAFB用于移植前评估和移植后早期监测。