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本文引用的文献

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Serum lipid profile in patients with acute myocardial infarction.急性心肌梗死患者的血清脂质谱
Indian J Clin Biochem. 2004 Jan;19(1):67-70. doi: 10.1007/BF02872393.
2
The acute phase response inhibits reverse cholesterol transport.急性期反应会抑制胆固醇逆向转运。
J Lipid Res. 2010 Apr;51(4):682-4. doi: 10.1194/jlr.E005454. Epub 2010 Jan 13.
3
HDL as a biomarker, potential therapeutic target, and therapy.高密度脂蛋白作为一种生物标志物、潜在治疗靶点及治疗手段。
Diabetes. 2009 Dec;58(12):2711-7. doi: 10.2337/db09-0538.
4
HDL biogenesis and functions: role of HDL quality and quantity in atherosclerosis.高密度脂蛋白的生成和功能：高密度脂蛋白质量和数量在动脉粥样硬化中的作用。
Atherosclerosis. 2010 Jan;208(1):3-9. doi: 10.1016/j.atherosclerosis.2009.05.034. Epub 2009 Jun 6.
5
The HDL proteome: a marker--and perhaps mediator--of coronary artery disease.高密度脂蛋白蛋白质组：冠状动脉疾病的一个标志物——或许还是介质。
J Lipid Res. 2009 Apr;50 Suppl(Suppl):S167-71. doi: 10.1194/jlr.R800097-JLR200. Epub 2008 Dec 5.
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Lipid binding domains: more than simple lipid effectors.脂质结合结构域：不仅仅是简单的脂质效应器。
J Lipid Res. 2009 Apr;50 Suppl(Suppl):S299-304. doi: 10.1194/jlr.R800078-JLR200. Epub 2008 Nov 13.
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HDL remodeling during the acute phase response.急性期反应期间的高密度脂蛋白重塑
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Molecular structure of low density lipoprotein: current status and future challenges.低密度脂蛋白的分子结构：现状与未来挑战
Eur Biophys J. 2009 Feb;38(2):145-58. doi: 10.1007/s00249-008-0368-y. Epub 2008 Sep 17.
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Lipid levels in the post-acute coronary syndrome setting: destabilizing another myth?急性冠状动脉综合征后血脂水平：又一个误区被打破？
J Am Coll Cardiol. 2008 Apr 15;51(15):1446-7. doi: 10.1016/j.jacc.2007.12.039.
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Lipid levels after acute coronary syndromes.急性冠状动脉综合征后的血脂水平。
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急性冠状动脉综合征后血清脂质的改变及其在临床实践中的重要性。

The modification of serum lipids after acute coronary syndrome and importance in clinical practice.

作者信息

Balci Bahattin

机构信息

The University of Kafkas, Faculty of Medicine, Department of Cardiology, 36100, KARS, Turkey.

出版信息

Curr Cardiol Rev. 2011 Nov;7(4):272-6. doi: 10.2174/157340311799960690.

DOI:10.2174/157340311799960690
PMID:22758629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3322446/
Abstract

Atherosclerosis is a pathology characterized by low-grade vascular inflammation rather than a mere accumulation of lipids. Inflammation is central at all stages of atherosclerosis. Acute coronary syndrome significantly affects the concentration and composition of the lipids and lipoproteins in plasma. Plasma triglyceride and very low density lipoprotein levels increase, while high density lipoprotein, low density lipoprotein and total cholesterol levels decrease. Early treatment of hyperlipidemia provides potential benefits. However, post-event changes in lipid and lipoproteins lead to delays in the choice of the treatment. This review focuses on the mechanism and the clinical importance of the relevant changes.

摘要

动脉粥样硬化是一种以低度血管炎症为特征的病理状态，而非仅仅是脂质的堆积。炎症在动脉粥样硬化的各个阶段都起着核心作用。急性冠状动脉综合征会显著影响血浆中脂质和脂蛋白的浓度及组成。血浆甘油三酯和极低密度脂蛋白水平升高，而高密度脂蛋白、低密度脂蛋白和总胆固醇水平降低。高脂血症的早期治疗具有潜在益处。然而，事件发生后脂质和脂蛋白的变化会导致治疗选择的延迟。本综述聚焦于相关变化的机制及临床重要性。