Balci Bahattin
The University of Kafkas, Faculty of Medicine, Department of Cardiology, 36100, KARS, Turkey.
Curr Cardiol Rev. 2011 Nov;7(4):272-6. doi: 10.2174/157340311799960690.
Atherosclerosis is a pathology characterized by low-grade vascular inflammation rather than a mere accumulation of lipids. Inflammation is central at all stages of atherosclerosis. Acute coronary syndrome significantly affects the concentration and composition of the lipids and lipoproteins in plasma. Plasma triglyceride and very low density lipoprotein levels increase, while high density lipoprotein, low density lipoprotein and total cholesterol levels decrease. Early treatment of hyperlipidemia provides potential benefits. However, post-event changes in lipid and lipoproteins lead to delays in the choice of the treatment. This review focuses on the mechanism and the clinical importance of the relevant changes.
动脉粥样硬化是一种以低度血管炎症为特征的病理状态,而非仅仅是脂质的堆积。炎症在动脉粥样硬化的各个阶段都起着核心作用。急性冠状动脉综合征会显著影响血浆中脂质和脂蛋白的浓度及组成。血浆甘油三酯和极低密度脂蛋白水平升高,而高密度脂蛋白、低密度脂蛋白和总胆固醇水平降低。高脂血症的早期治疗具有潜在益处。然而,事件发生后脂质和脂蛋白的变化会导致治疗选择的延迟。本综述聚焦于相关变化的机制及临床重要性。