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那他霉素在实验性茄病镰刀菌角膜炎中的抗真菌疗效

Antifungal efficacy of natamycin in experimental fusarium solani keratitis.

作者信息

Dong Xian-Hui, Gao Wei-Juan, He Xiao-Ping

机构信息

Laboratory of Spinal Cord Injury and Rehabilitation of Chengde Medical University, Chengde 067000, Hebei Province, China.

出版信息

Int J Ophthalmol. 2012;5(2):143-6. doi: 10.3980/j.issn.2222-3959.2012.02.05. Epub 2012 Apr 18.

Abstract

AIM

To evaluate the efficacy of topical administration Natamycin, which is produced by China, in an experimental rabbit model of Fusarium solani keratitis, to provide experimental basis for the application of clinical safety.

METHODS

Fusarium solani was induced in the right eye of 30 New Zealand rabbits. Forty-eight hours after inoculation, the animals were divided into 3 different treatment groups, 10 rabbit eyes of each group: Group 1 (Natamycin) treated with topical Natamycin, group 2 (Natacyn) treated with topical Natacyn, group 3 (control) treated with topical saline solution. The eyes of each group was examined clinically with slit lamp using ulcer scoring system on day 4, 10, 15, and 21 for status of healing, corneal vascularisation, iritis, hypopyon and macular nebula. The findings were recorded on day 10 and day 21.

RESULTS

Ulcer score on day 10, day 15, day 21: The score of Natamycin group are 1.45±0.16, 1.08±0.11, 0.70±0.40. The score of Natacyn group are 1.35±0.12, 1.10±0.12, 0.65±0.35. the score of control group are 1.30±0.08, 3.63±0.28, 3.80±0.16. Natamycin group and Natacyn group were different from control group (P<0.01). There is no difference between Natamycin group and Natacyn group. Status of healing on day 10 and day 21: The cure rate of the Natamycin group is 90% on day 10, and 100% on day 21. The cure rate of the Natacyn group is 80% on day 10, and 100% on day 21.Natamycin group and Natacyn group were different from control group (P<0.01). There is no difference between Natamycin group and Natacyn group. Corneal vascularisation, iritis, hypopyon and macular nebula on day 10 and day 21: in Natamycin group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 2,0,0,2. In Natacyn group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 1,0,0,2. In control group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 9,9,8,9.Natamycin group and Natacyn group were different from control group (P<0.01). There is no difference between Natamycin group and Natacyn group.

CONCLUSION

Natamycin was found to be effective in fungal keratitis, similar to Natacyn, and it can stop the corner vascularisation, iritis, hypopyon and macular nebula to happen. Natamyin manufactured in China is effective against fungal keratitis, with esay availability and low toxicity in its use.

摘要

目的

评价国产那他霉素局部给药在茄病镰刀菌角膜炎实验兔模型中的疗效,为其临床安全应用提供实验依据。

方法

对30只新西兰兔右眼诱发茄病镰刀菌感染。接种48小时后,将动物分为3个不同治疗组,每组10只兔眼:第1组(那他霉素组)局部应用那他霉素治疗,第2组(匹马霉素组)局部应用匹马霉素治疗,第3组(对照组)局部应用生理盐水溶液。在第4、10、15和21天,使用裂隙灯通过溃疡评分系统对每组兔眼进行临床检查,观察愈合情况、角膜血管化、虹膜炎、前房积脓和斑翳情况。在第10天和第2l天记录结果。

结果

第10、15、21天溃疡评分:那他霉素组评分分别为1.45±0.16、1.08±0.11、0.70±0.40。匹马霉素组评分分别为1.35±0.12、1.10±0.12、0.65±0.35。对照组评分分别为1.30±0.08、3.63±0.28、3.80±0.16。那他霉素组和匹马霉素组与对照组不同(P<0.01)。那他霉素组和匹马霉素组之间无差异。第10天和第21天愈合情况:那他霉素组第10天治愈率为90%,第21天为100%。匹马霉素组第10天治愈率为80%,第21天为100%。那他霉素组和匹马霉素组与对照组不同(P<0.01)。那他霉素组和匹马霉素组之间无差异。第10天和第21天角膜血管化、虹膜炎、前房积脓和斑翳情况:那他霉素组出现角膜血管化、虹膜炎、前房积脓和斑翳的兔眼数分别为2、0、0、2。匹马霉素组出现角膜血管化、虹膜炎、前房积脓和斑翳的兔眼数分别为1、0、0、2。对照组出现角膜血管化、虹膜炎、前房积脓和斑翳的兔眼数分别为9、9、8、9。那他霉素组和匹马霉素组与对照组不同(P<0.01)。那他霉素组和匹马霉素组之间无差异。

结论

发现那他霉素在真菌性角膜炎中与匹马霉素效果相似,可阻止角膜血管化、虹膜炎、前房积脓和斑翳的发生。国产那他霉素对真菌性角膜炎有效,使用方便且毒性低。

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