Vincent Stephen J, Collins Michael J, Read Scott A, Carney Leo G
Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Brisbane, Queensland, Australia.
Vision Res. 2012 Aug 1;66:39-48. doi: 10.1016/j.visres.2012.06.016. Epub 2012 Jul 2.
This study compared the corneal and total higher order aberrations between the fellow eyes in monocular amblyopia. Nineteen amblyopic subjects (8 refractive and 11 strabismic) (mean age 30 ± 11 years) were recruited. A range of biometric and optical measurements were collected from the amblyopic and non-amblyopic eye including; axial length, corneal topography and total higher order aberrations. For a sub-group of eleven non-presbyopic subjects (6 refractive and 5 strabismic amblyopes, mean age 29 ± 10 years) total higher order aberrations were also measured during accommodation (2.5D stimuli). Amblyopic eyes were significantly shorter and more hyperopic compared to non-amblyopic eyes and the interocular difference in axial length correlated with both the magnitude of anisometropia and amblyopia (both p<0.01). Significant differences in higher order aberrations were observed between fellow eyes, which varied with the type of amblyopia. Refractive amblyopes displayed higher levels of 4th order corneal aberrations C(4,0)(spherical aberration), C(4,2)(secondary astigmatism 90°) and C(4,-2)(secondary astigmatism along 45°) in the amblyopic eye compared to the non-amblyopic eye. Strabismic amblyopes exhibited significantly higher levels of C(3,3)(trefoil) in the amblyopic eye for both corneal and total higher order aberrations. During accommodation, the amblyopic eye displayed a significantly greater lag of accommodation compared to the non-amblyopic eye, while the changes in higher order aberrations were similar in magnitude between fellow eyes. Asymmetric visual experience during development appears to be associated with asymmetries in higher order aberrations, in some cases proportional to the magnitude of anisometropia and dependent upon the amblyogenic factor.
本研究比较了单眼弱视患者双眼之间的角膜高阶像差和总高阶像差。招募了19名弱视受试者（8名屈光不正性和11名斜视性）（平均年龄30±11岁）。从弱视眼和非弱视眼中收集了一系列生物测量和光学测量数据，包括：眼轴长度、角膜地形图和总高阶像差。对于11名非老视受试者的亚组（6名屈光不正性和5名斜视性弱视患者，平均年龄29±10岁），还在调节时（2.5D刺激）测量了总高阶像差。与非弱视眼相比，弱视眼明显更短且更远视，眼轴长度的双眼差异与屈光参差的程度和弱视均相关（均p<0.01）。在双眼之间观察到高阶像差存在显著差异，且因弱视类型而异。与非弱视眼相比，屈光不正性弱视患者的弱视眼角膜4阶像差C(4,0)（球差）、C(4,2)（90°继发性散光）和C(4,-2)（45°继发性散光）水平更高。斜视性弱视患者的弱视眼角膜和总高阶像差的C(3,3)（三叶形）水平均显著更高。在调节过程中，与非弱视眼相比，弱视眼的调节滞后明显更大，而双眼之间高阶像差的变化幅度相似。发育过程中不对称的视觉体验似乎与高阶像差的不对称有关，在某些情况下与屈光参差的程度成比例，并取决于致弱视因素。
