Vogler B R, Vetsch E, Wernick M B, Sydler T, Wiederkehr D D
Clinic for Zoo Animals, Exotic Pets and Wildlife.
J Comp Pathol. 2012 Nov;147(4):452-4. doi: 10.1016/j.jcpa.2012.04.005. Epub 2012 Jul 5.
Leiomyosarcoma was diagnosed in the heart of a 3-year-old female guinea pig. Neoplastic tissue was located in the ventricular septum extending into the right ventricular lumen, but was not obvious grossly. Microscopically, the mass was nodular and infiltrative and was composed of streams and bundles of spindle cells. Immunohistochemically, the neoplastic cells expressed vimentin and α-smooth muscle actin. There was no cross striation of the muscle cells. This is the first report of cardiac leiomyosarcoma in a guinea pig.
一只3岁雌性豚鼠的心脏被诊断出患有平滑肌肉瘤。肿瘤组织位于室间隔，延伸至右心室腔，但肉眼观察并不明显。显微镜下，肿块呈结节状且具有浸润性，由梭形细胞束和条索组成。免疫组化显示，肿瘤细胞表达波形蛋白和α-平滑肌肌动蛋白。肌细胞无横纹。这是豚鼠心脏平滑肌肉瘤的首例报道。
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