将心肌成纤维细胞在体转化为心肌细胞。

Turning cardiac fibroblasts into cardiomyocytes in vivo.

机构信息

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

出版信息

Trends Mol Med. 2012 Oct;18(10):575-6. doi: 10.1016/j.molmed.2012.06.009. Epub 2012 Jul 5.

DOI:10.1016/j.molmed.2012.06.009

Abstract

Murine fibroblasts have previously been reprogrammed to form cardiomyocytes in vitro, but recent studies have demonstrated direct conversion of cardiac fibroblasts into cardiomyocytes in vivo. This is accomplished by delivering transcription factors or microRNAs to the mouse heart and may represent a new avenue for regenerative cardiac therapy.

摘要

先前已经有研究表明，在体外条件下，鼠源成纤维细胞可以被重编程为心肌细胞；但最近的研究又表明，在体条件下，心肌成纤维细胞可以直接转化为心肌细胞。该方法通过向小鼠心脏中递送转录因子或 microRNAs 来实现，这可能代表了一种用于心脏再生治疗的新方法。