Ter Arkh. 2012;84(4):74-8.
Cardiac arrhythmias and conduction disturbances are an important cause of morbidity and mortality in many countries all over the world Etiology of these disorders remains unclear in many patients. Experimental and clinical studies show that autoimmune reactions may be involved in development of arrhythmias and cardiac blocks. Precise identification of an autoantibody-mediated mechanism opens new perspectives in the treatment and prevention of cardiac arrhythmias including use of immunosuppressive agents or removal of autoantibodies by absorption technique. The review focuses on cardiac autoantigens, autoantibodies and their interactions that may be involved in development of cardriac arrhythmias.
在世界上许多国家，心律失常和传导障碍是发病和死亡的重要原因。在许多患者中，这些疾病的病因仍不清楚。实验和临床研究表明，自身免疫反应可能参与心律失常和心脏传导阻滞的发生。精确识别自身抗体介导的机制为心律失常的治疗和预防开辟了新的前景，包括使用免疫抑制剂或通过吸附技术去除自身抗体。这篇综述聚焦于可能参与心律失常发生的心脏自身抗原、自身抗体及其相互作用。
