Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Biological Sciences, Brain Sciences, Toronto, ON, Canada.
J Alzheimers Dis. 2012;32(2):267-72. doi: 10.3233/JAD-2012-100732.
Accumulation of amyloid-β peptides (Aβ) and cholinergic degeneration are hallmarks of Alzheimer's disease (AD). In a triple transgenic mouse model of AD (3xTg-AD), soluble Aβ42 levels were detected in the septum by 2 months of age, reaching their highest levels at 3-6 months and decreasing at 12 months. Deficits in the number of septal cholinergic neurons and the length of hippocampal cholinergic axons were observed starting at 4 months in 3xTg-AD mice. Our results show that septal Aβ and septohippocampal cholinergic pathology in 3xTg-AD mice occur at an early stage of disease.
淀粉样β肽（Aβ）的积累和胆碱能变性是阿尔茨海默病（AD）的标志。在 AD 的三转基因小鼠模型（3xTg-AD）中，2 个月大时在隔核中检测到可溶性 Aβ42 水平，3-6 个月时达到最高水平，12 个月时降低。3xTg-AD 小鼠从 4 个月开始出现隔核胆碱能神经元数量减少和海马胆碱能轴突长度缩短。我们的结果表明，3xTg-AD 小鼠的隔核 Aβ和隔海马胆碱能病理学发生在疾病的早期阶段。
