Adis, Auckland, New Zealand.
CNS Drugs. 2012 Aug 1;26(8):717-23. doi: 10.2165/11208930-000000000-00000.
Intramuscular onabotulinumtoxinA (onaBoNTA; BOTOX®) is indicated for headache prophylaxis in adults with chronic migraine. According to pooled results from two large trials, treatment with up to five cycles of onaBoNTA (155-195 units/cycle) at 12-week intervals was effective in reducing headache symptoms, decreasing headache-related disability and improving health-related quality of life in patients with chronic migraine. OnaBoNTA was generally well tolerated in these trials, with an adverse event profile that was consistent with that of the neurotoxin when injected into head and neck muscles.
肌肉内注射肉毒毒素 A （onaBoNTA；肉毒素）被批准用于预防慢性偏头痛成人的头痛。根据两项大型试验的汇总结果，每 12 周接受多达五个周期的 onaBoNTA（155-195 个单位/周期）治疗可有效减轻头痛症状，降低与头痛相关的残疾，并改善慢性偏头痛患者的健康相关生活质量。在这些试验中，onaBoNTA 通常具有良好的耐受性，其不良事件谱与注射到头颈部肌肉的神经毒素一致。
Zotero 插件