Shimane University, Japan.
J Cogn Neurosci. 2012 Nov;24(11):2186-98. doi: 10.1162/jocn_a_00269. Epub 2012 Jul 11.
Aging is related to cognitive decline, and it has been reported that aging disrupts some resting state brain networks. However, most studies have focused on the default mode network and ignored other resting state networks. In this study, we measured resting state activity using fMRI and explored whether cognitive decline with aging is related to disrupted resting state networks. Independent component analysis was used to evaluate functional connectivity. Notably, the connectivity within the salience network that consisted of the bilateral insula and the anterior cingulated cortex decreased with aging; the impairment of functional connectivity was correlated with measured decreases in individual cognitive abilities. Furthermore, certain internetwork connectivities (salience to auditory, default mode to visual, etc.) also decreased with aging. These results suggest that (1) aging affects not only the default mode network but also other networks, specifically the salience network; (2) aging affects internetwork connectivity; and (3) disruption of the salience network is related to cognitive decline in elderly people.
衰老是与认知能力下降相关的，据报道，衰老会破坏一些静息态脑网络。然而，大多数研究都集中在默认模式网络，而忽略了其他静息态网络。在这项研究中，我们使用 fMRI 测量静息态活动，并探讨了随着年龄增长认知能力下降是否与静息态网络的破坏有关。独立成分分析用于评估功能连接。值得注意的是，由双侧脑岛和前扣带皮层组成的显着性网络内的连接随着年龄的增长而下降；功能连接的损伤与个体认知能力的测量下降相关。此外，某些网络间连接（显着性到听觉、默认模式到视觉等）也随着年龄的增长而下降。这些结果表明：（1）衰老不仅影响默认模式网络，还影响其他网络，特别是显着性网络；（2）衰老影响网络间连接；（3）显着性网络的破坏与老年人的认知能力下降有关。
