Southwest Immunodiagnostics Inc., San Antonio, Texas 78229, USA.
Curr Opin Organ Transplant. 2012 Aug;17(4):427-32. doi: 10.1097/MOT.0b013e3283556ff2.
To highlight the role of histocompatibility testing in kidney paired donor (KPD) exchange programs as well as the new technological advances that may have an effect on KPD.
Technological advances in human leukocyte antigen (HLA) antibody identification using the Luminex single-antigen bead multiplexing platform have facilitated virtual cross-matching and the ability to accurately match donor/recipient pairs through KPD. A knowledge of the limitations of this assay is the key to proper interpretation of the data and maximization of this new technology. Novel assays such as C1q and Ig subclass identification may be useful in further determining which HLA antibodies are clinically relevant.
KPD is an established method for increasing access to transplantation for patients with incompatible live donors. Advances in histocompatibility testing have played a role in the success of KPD.
强调组织相容性检测在肾配对供者（KPD）交换项目中的作用，以及可能对 KPD 产生影响的新技术进展。
使用 Luminex 单抗原珠多重分析平台进行人类白细胞抗原（HLA）抗体鉴定的技术进步促进了虚拟交叉匹配，以及通过 KPD 准确匹配供体/受者对的能力。了解该检测的局限性是正确解释数据和最大限度利用这项新技术的关键。新型检测，如 C1q 和 Ig 亚类鉴定，可能有助于进一步确定哪些 HLA 抗体具有临床相关性。
KPD 是增加对不匹配活体供者移植患者获得移植机会的一种已确立的方法。组织相容性检测的进步在 KPD 的成功中发挥了作用。
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