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[精氨酸加压素对大鼠甲状腺的体外作用]

[Effect of arginine-vasopressin on the rat thyroid gland in vitro].

作者信息

Ditiateva G V, Krasnovskaia I A, Skopicheva V I

出版信息

Biull Eksp Biol Med. 1990 Oct;110(10):423-5.

PMID:2279099
Abstract

The response of the rat thyroid gland to arginine-vasopressin in vitro was studied to clear a possibility of a direct regulation of this gland by hypothalamic nonapeptide neurohormones. The function of the thyroid gland was estimated by thyrocyte height and quantity of the autoradiographs on a thyrocyte. AVP makes more active hormone synthesis in thyrocytes after 30 min of incubation and it stimulates both synthesis and secretion of the thyroid hormones in 2 hours of incubation. The higher concentrations of AVP activate the thyroid hormone synthesis but not the secretion.

摘要

研究了大鼠甲状腺在体外对精氨酸加压素的反应,以明确下丘脑九肽神经激素对该腺体直接调节的可能性。通过甲状腺细胞高度和甲状腺细胞上放射自显影片的数量来评估甲状腺的功能。孵育30分钟后,精氨酸加压素使甲状腺细胞中的激素合成更活跃,孵育2小时后,它刺激甲状腺激素的合成和分泌。较高浓度的精氨酸加压素激活甲状腺激素合成,但不激活分泌。

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