机体对 XBP-1 介导的未折叠蛋白反应在发育和免疫激活中的调控。
Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation.
机构信息
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
EMBO Rep. 2012 Sep;13(9):855-60. doi: 10.1038/embor.2012.100. Epub 2012 Jul 13.
Abstract
The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1--a G protein-coupled catecholamine receptor expressed in neurons--suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during development, only at the adult stage. Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation.
摘要
在细菌感染过程中，内质网（ER）中蛋白质折叠的需求增加会激活未折叠蛋白反应（UPR）。OCTR-1——一种在神经元中表达的 G 蛋白偶联儿茶酚胺受体——通过下调非典型 UPR 途径和 p38 MAPK 途径来抑制先天免疫。在这里，我们表明 OCTR-1 还在机体水平上调节由 XBP-1 控制的经典 UPR 途径。重要的是，XBP-1 在发育过程中不受 OCTR-1 的控制，仅在成年期受其控制。我们的结果表明，神经系统在发育和免疫激活过程中通过时间控制 UPR 途径来维持 ER 内稳态。
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2
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3
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