在头颈部鳞状细胞癌的组织病理学进展过程中，ATBF1 的核定位中断。
Interruption of nuclear localization of ATBF1 during the histopathologic progression of head and neck squamous cell carcinoma.
机构信息
Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia 30322, USA.
出版信息
Head Neck. 2013 Jul;35(7):1007-14. doi: 10.1002/hed.23077. Epub 2012 Jul 13.
Abstract
BACKGROUND
The AT-motif binding factor 1 (ATBF1) gene is frequently altered at the genetic level in several types of cancer, but its protein expression and subcellular localization have not been well studied in human cancers, including head and neck squamous cell carcinomas (HNSCCs).
METHODS
ATBF1 expression and localization were examined in 5 cell lines and 197 clinical specimens of HNSCC, and correlated with pathologic and clinical characteristics.
RESULTS
ATBF1 was predominantly localized in the nucleus of hyperplastic squamous epithelium. Whereas nuclear ATBF1 dramatically decreased in invasive tumors (p = .0012), cytoplasmic ATBF1 levels progressively increased from dysplasia to invasive tumors (p < .0001), and the increase correlated with poor survival. Reduced nuclear ATBF1 level was also detected in HNSCC cell lines.
CONCLUSIONS
Nuclear localization of ATBF1 is frequently interrupted in HNSCC, and the interruption is significantly associated with the progression of HNSCC. The cytoplasmic ATBF1 level could be useful for predicting patient survival.
摘要
背景
AT motif 结合因子 1（ATBF1）基因在多种类型的癌症中经常在遗传水平上发生改变，但在人类癌症中，包括头颈部鳞状细胞癌（HNSCC），其蛋白表达和亚细胞定位尚未得到很好的研究。
方法
在 5 个细胞系和 197 例 HNSCC 临床标本中检测了 ATBF1 的表达和定位，并与病理和临床特征相关联。
结果
ATBF1 主要定位于增生性鳞状上皮的核内。核内 ATBF1 在侵袭性肿瘤中显著减少（p =.0012），而细胞质 ATBF1 水平从发育不良到侵袭性肿瘤逐渐增加（p <.0001），并且这种增加与不良预后相关。在 HNSCC 细胞系中也检测到核内 ATBF1 水平降低。
结论
HNSCC 中核内 ATBF1 的定位经常中断，这种中断与 HNSCC 的进展显著相关。细胞质 ATBF1 水平可用于预测患者的生存。
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2
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CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300. doi: 10.3322/caac.20073. Epub 2010 Jul 7.
3
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4
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