Michael G DeGroote Institute for Pain Research and Care, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
J Pain Res. 2012;5:175-92. doi: 10.2147/JPR.S26367. Epub 2012 Jun 20.
The aim of this study was to compare primary sensory neurons in controls and in an animal neuropathic pain model in order to understand which types of neurons undergo changes associated with peripheral neuropathy. On the basis of intracellular recordings in vivo from somata, L4 sensory dorsal root ganglion neurons were categorized according to action potential configuration, conduction velocity, and receptive field properties to mechanical stimuli.
Intracellular recordings were made from functionally identified dorsal root ganglion neurons in vivo in the Mosconi and Kruger animal model of peripheral neuropathic pain.
In this peripheral neuropathy model, a specific population of Aβ-fiber low threshold mechanoreceptor neurons, which respond normally to innocuous mechanical stimuli, exhibited differences in action potential configuration and conduction velocity when compared with control animals. No abnormal conduction velocity, action potential shapes, or tactile sensitivity of C-fiber neurons were encountered.
This study provides evidence for defining a potential role of Aβ-fiber low threshold mechanoreceptor neurons that might contribute to peripheral neuropathic pain.
本研究旨在比较对照和动物神经病理性疼痛模型中的初级感觉神经元，以了解哪些类型的神经元发生与周围神经病变相关的变化。基于活体胞内记录，根据动作电位构型、传导速度和机械刺激感受野特性对 L4 感觉背根神经节神经元进行分类。
在 Mosconi 和 Kruger 周围神经病理性疼痛动物模型中，对体内功能鉴定的背根神经节神经元进行胞内记录。
在该周围神经病变模型中，与对照动物相比，对无害机械刺激正常反应的 Aβ 纤维低阈值机械感受器神经元的特定群体，其动作电位构型和传导速度存在差异。未遇到 C 纤维神经元的异常传导速度、动作电位形态或触觉敏感性。
本研究为定义 Aβ 纤维低阈值机械感受器神经元的潜在作用提供了证据，该作用可能有助于周围神经病理性疼痛。
