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在聚四氟乙烯(PTFE)-膝下动脉旁路移植远端吻合处使用的静脉套环的类型、形状和体积对通畅性的影响。

The effect on patency of type, shape and volume of a vein collar used at the distal anastomis of PTFE-bypass to arteries below-knee.

作者信息

Lundgren F

机构信息

Scandinavian Miller Collar Study, Sweden.

出版信息

Int Angiol. 2012 Aug;31(4):348-55.

Abstract

AIM

The aim of this paper was to study the effect on patency rate of different types of vein collar (Miller's original or St Mary's boot), different length/height shapes of vein collar, and different vein collar volumes at the distal anastomosis of PTFE-bypass grafts to below-knee arteries in patients with critical limb ischemia.

METHODS

One hundred eighty patients operated on with PTFE-bypass to below-knee arteries with a vein collar at the distal anastomosis were analyzed. They were recruited from a prospective randomized trial evaluating the effect of adding a vein collar to the distal anastomosis. Primary patency rate of the reconstructions were assessed against three factors: the type, shape, and volume of the vein collar. Univariate analysis was performed with the help of plotted Kaplan-Meier lifetable curves and log-rank tests and multivariate analysis with Cox proportional hazards regression.

RESULTS

Type of vein collar had no influence on primary patency (logrank-test, χ(2)=0.8, df=1, P=0.377, N.=180). A length/height ratio of the vein collar between 1.18 and 1.63 were advantageous for primary patency but the effect was not statistically significant (logrank-test, chisq=5.5, df=2, P=0.063, N.=177). A large volume of the vein collar enhanced primary patency (logrank-test, chisq=6, df=2, P=0.050, N.=173). In the multivariate analysis, however, a larger volume and a length/height ratio between 1.18 and 1.63 as well as > 1.63 reduce the risk of graft failure with 48% (P=0.00006), 58% (P=0.007), 58% (P=0.004), respectively, while vein collar type had no effect on primary patency.

CONCLUSION

This prospective observational study indicates that if a vein collar is used at the distal anastomosis of a PTFE-bypass to below-knee arteries it should be long compared to height and large in volume to improve primary patency rate, while the type of vein collar does not appear to matter.

摘要

目的

本文旨在研究不同类型的静脉套环(米勒原版或圣玛丽靴型)、不同长宽/高形状的静脉套环以及不同静脉套环体积对严重肢体缺血患者的聚四氟乙烯(PTFE)旁路移植至膝下动脉远端吻合口通畅率的影响。

方法

分析180例行PTFE旁路移植至膝下动脉且在远端吻合口使用静脉套环的患者。这些患者来自一项评估在远端吻合口添加静脉套环效果的前瞻性随机试验。根据静脉套环的类型、形状和体积这三个因素评估重建血管的初始通畅率。借助绘制的Kaplan-Meier生存表曲线和对数秩检验进行单因素分析,并用Cox比例风险回归进行多因素分析。

结果

静脉套环类型对初始通畅率无影响(对数秩检验,χ(2)=0.8,自由度=1,P=0.377,N=180)。静脉套环的长宽/高比在1.18至1.63之间对初始通畅率有利,但效果无统计学意义(对数秩检验,chisq=5.5,自由度=2,P=0.063,N=177)。较大体积的静脉套环可提高初始通畅率(对数秩检验,chisq=6,自由度=2,P=0.050,N=173)。然而,在多因素分析中,较大体积以及长宽/高比在1.18至1.63之间和大于1.63分别使移植失败风险降低48%(P=0.00006)、58%(P=0.007)、58%(P=0.004),而静脉套环类型对初始通畅率无影响。

结论

这项前瞻性观察性研究表明,如果在PTFE旁路移植至膝下动脉的远端吻合口使用静脉套环,其长度应相对高度较长且体积较大,以提高初始通畅率,而静脉套环的类型似乎无关紧要。

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