重新审视 LKB1-AMPK 轴。
LKB1-AMPK axis revisited.
机构信息
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
出版信息
Cell Res. 2012 Dec;22(12):1617-20. doi: 10.1038/cr.2012.108. Epub 2012 Jul 17.
Abstract
The LKB1 tumor suppressor encodes a serine-threonine kinase whose substrates control cell metabolism, polarity, and motility. LKB1 is a major mediator of the cellular response to energy stress via activation of the master regulator of energy homeostasis, AMPK. While mutational inactivation of LKB1 promotes the development of many types of epithelial cancer, a recent report in Nature by Jeon et al. demonstrates that the LKB1-AMPK pathway can also have an unexpected positive role in tumorigenesis, acting to maintain metabolic homeostasis and attenuate oxidative stress thereby supporting the survival of cancer cells.
摘要
抑癌基因 LKB1 编码一种丝氨酸/苏氨酸激酶，其底物可控制细胞代谢、极性和运动。LKB1 是细胞对能量应激反应的主要介质，通过激活能量稳态的主调控因子 AMPK 来实现。虽然 LKB1 的突变失活会促进多种上皮癌的发生，但 Jeon 等人在《自然》杂志上的最新报告表明，LKB1-AMPK 通路在肿瘤发生中也可能具有出人意料的积极作用，其作用是维持代谢平衡并减轻氧化应激，从而支持癌细胞的存活。
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