起源于幽门腺腺瘤的十二指肠腺癌并文献简要回顾
Duodenal adenocarcinoma arising from a pyloric gland adenoma with a brief review of the literature.
作者信息
Khor T S, Brown I, Kattampallil J, Yusoff I, Kumarasinghe M P
机构信息
Department of Histopathology, PathWest, Fremantle Hospital, Fremantle, Australia.
出版信息
BMJ Case Rep. 2010 Dec 29;2010:bcr1020103385. doi: 10.1136/bcr.10.2010.3385.
Abstract
Pyloric gland-type adenoma of the duodenum with documented malignant progression is rare. A case is presented of an 87-year-old man with bloating and nausea, who on investigation was found to have a polyp on the anteroinferior wall of the duodenal cap. Histologic examination of the polyp showed features of a pyloric gland adenoma (PGA) demonstrating the full spectrum of progression from low- to high-grade dysplasia and finally invasive adenocarcinoma. The carcinoma showed gastric-type differentiation highlighted by its mucin immunohistochemistry profile and was of advanced stage with lymph node metastasis. The literature on PGAs and the little documentations on progression to carcinoma in duodenal PGAs are reviewed.
摘要
十二指肠幽门腺型腺瘤伴恶性进展的病例罕见。本文报告一例87岁男性，有腹胀和恶心症状，经检查发现十二指肠球部前下壁有一息肉。息肉的组织学检查显示为幽门腺腺瘤（PGA），呈现出从低级别到高级别发育异常最终发展为浸润性腺癌的全过程。该癌表现出胃型分化，其粘蛋白免疫组化特征突出，且处于晚期并伴有淋巴结转移。本文对PGA的相关文献以及十二指肠PGA进展为癌的少量文献进行了综述。
相似文献
1
Duodenal adenocarcinoma arising from a pyloric gland adenoma with a brief review of the literature.起源于幽门腺腺瘤的十二指肠腺癌并文献简要回顾
BMJ Case Rep. 2010 Dec 29;2010:bcr1020103385. doi: 10.1136/bcr.10.2010.3385.
2
A case of pyloric gland adenoma with high-grade dysplasia in the duodenum arising from heterotopic gastric mucosa observed over 5 years.一例源于异位胃黏膜的十二指肠幽门腺腺瘤伴高级别异型增生，观察5年。
Clin J Gastroenterol. 2023 Feb;16(1):26-31. doi: 10.1007/s12328-022-01721-6. Epub 2022 Oct 28.
3
Clinicopathological features of pyloric gland adenomas of the duodenum: a multicentre study of 57 cases.十二指肠幽门腺腺瘤的临床病理特征：57 例多中心研究。
Histopathology. 2020 Feb;76(3):404-410. doi: 10.1111/his.13996. Epub 2019 Dec 1.
4
Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma.幽门腺腺瘤：一种与胃小凹型腺瘤不同的实体。
Am J Surg Pathol. 2009 Feb;33(2):186-93. doi: 10.1097/PAS.0b013e31817d7ff4.
5
Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum.胃和十二指肠胃泌素瘤中频繁的 GNAS 和 KRAS 突变。
J Pathol. 2013 Mar;229(4):579-87. doi: 10.1002/path.4153. Epub 2013 Feb 4.
6
'Pyloric gland-type adenoma' arising in heterotopic gastric mucosa of the duodenum, with dysplastic progression of the gastric type.十二指肠异位胃黏膜中出现的“幽门腺型腺瘤”，伴有胃型的发育异常进展。
Virchows Arch. 1999 Oct;435(4):452-7. doi: 10.1007/s004280050425.
7
Pyloric Gland Adenoma (PGA) of the Gallbladder: A Unique and Distinct Tumor from PGAs of the Stomach, Duodenum, and Pancreas.胆囊胃泌素瘤（PGA）：一种独特且与胃、十二指肠和胰腺 PGA 不同的肿瘤。
Am J Surg Pathol. 2018 Sep;42(9):1237-1245. doi: 10.1097/PAS.0000000000001117.
8
9
[A case of flat elevated type carcinoma in adenoma of the duodenum with gastric cancer].[十二指肠腺瘤伴胃癌中的扁平隆起型癌一例]
Gan To Kagaku Ryoho. 2006 Nov;33(12):1878-80.
10
Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases.胃幽门腺腺瘤：67 例多中心临床病理研究。
Histopathology. 2018 May;72(6):1007-1014. doi: 10.1111/his.13460. Epub 2018 Mar 5.
引用本文的文献
1
Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case series.30例幽门腺腺瘤的临床病理特征：单中心病例系列研究
BMC Gastroenterol. 2025 Jul 7;25(1):507. doi: 10.1186/s12876-025-04110-8.
2
Proteome-based molecular subtyping and therapeutic target prediction in gastric cancer.基于蛋白质组学的胃癌分子亚型分类和治疗靶点预测。
Mol Oncol. 2024 Jun;18(6):1437-1459. doi: 10.1002/1878-0261.13654. Epub 2024 Apr 16.
3
Clinicopathological characteristics of duodenal epithelial neoplasms: Focus on tumors with a gastric mucin phenotype (pyloric gland-type tumors).十二指肠上皮性肿瘤的临床病理特征：聚焦具有胃黏液表型的肿瘤（幽门腺型肿瘤）。
PLoS One. 2017 Apr 4;12(4):e0174985. doi: 10.1371/journal.pone.0174985. eCollection 2017.
本文引用的文献
1
Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma.幽门腺腺瘤：一种与胃小凹型腺瘤不同的实体。
Am J Surg Pathol. 2009 Feb;33(2):186-93. doi: 10.1097/PAS.0b013e31817d7ff4.
2
DNA copy number profiles of gastric cancer precursor lesions.胃癌前病变的DNA拷贝数图谱。
BMC Genomics. 2007 Oct 1;8:345. doi: 10.1186/1471-2164-8-345.
3
Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach.胃型高分化腺癌及胃幽门腺腺瘤
Gastric Cancer. 2006;9(3):177-84. doi: 10.1007/s10120-006-0381-8.
4
Gastric foveolar metaplasia with dysplastic changes in Brunner gland hyperplasia: possible precursor lesions for Brunner gland adenocarcinoma.胃小凹化生伴十二指肠腺增生的发育异常改变：十二指肠腺腺癌可能的前驱病变。
Am J Surg Pathol. 2005 Nov;29(11):1442-8. doi: 10.1097/01.pas.0000180449.15827.88.
5
Pyloric gland adenoma arising in Barrett's esophagus with mucin immunohistochemical and molecular cytogenetic evaluation.伴有黏液免疫组化及分子细胞遗传学评估的巴雷特食管中发生的幽门腺腺瘤
Virchows Arch. 2005 May;446(5):537-41. doi: 10.1007/s00428-004-1185-z. Epub 2005 Apr 19.
6
Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum.直肠异位胃体黏膜中具有胃分化的腺瘤（所谓的幽门腺腺瘤）。
Virchows Arch. 2005 May;446(5):542-5. doi: 10.1007/s00428-005-1242-2. Epub 2005 Apr 19.
7
MUC5B expression in gastric carcinoma: relationship with clinico-pathological parameters and with expression of mucins MUC1, MUC2, MUC5AC and MUC6.黏蛋白5B（MUC5B）在胃癌中的表达：与临床病理参数以及黏蛋白MUC1、MUC2、MUC5AC和MUC6表达的关系
Virchows Arch. 2004 Mar;444(3):224-30. doi: 10.1007/s00428-003-0968-y. Epub 2004 Jan 31.
8
Pyloric gland adenoma: a clinico-pathological analysis of 90 cases.幽门腺腺瘤：90例临床病理分析
Virchows Arch. 2003 Apr;442(4):317-21. doi: 10.1007/s00428-002-0750-6. Epub 2003 Mar 26.
9
Metaplasia of the duodenum shows a Helicobacter pylori-correlated differentiation into gastric-type protein expression.十二指肠化生表现出与幽门螺杆菌相关的向胃型蛋白表达的分化。
Hum Pathol. 2003 Feb;34(2):156-65. doi: 10.1053/hupa.2003.15.
10
Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glands.十二指肠第二部的胃型腺癌，组织发生学上与Brunner腺增生及胃小凹化生相关。
Virchows Arch. 2002 Jun;440(6):655-9. doi: 10.1007/s00428-002-0615-z. Epub 2002 Feb 21.
Zotero 插件