Sun Zezhan, Sun Jiao, Qin Li, Kang Yong
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Zhongguo Zhong Yao Za Zhi. 2012 May;37(9):1212-8.
To study the effect of quaternary ammonium salt of chitosan (HACC) in purifying aqueous extracts of Zhisou Dingchuan oral solution.
Modified quaternary ammonium salt of chitosan was used to flocculate aqueous extracts of Zhisou dingchuan oral solution, with turbidity degree and the retention rate of ephedrine and glycyrrhizin as indicators, to detect the influences of flocculant dosage, suspension temperature, mixing speed and time on flocculation effect. The optimum process conditions were found through orthogonal experimental design.
The optimum process conditions: the flocculation temperature 30 degrees C, HACC's dosage 0.4 g x L(-1), the fast mixing speed 500 r x min(-1) and its time 1 min, the slow mixing speed 50 r x min(-1) and it time 2.4 10 min. Under the conditions, the retention rate of ephedrine was 97.6%, the turbidity degree was 1.1 NTU and 2.8 NTU after 30 days.
HACC can be used to purify aqueous extracts of Zhisou Dingchuan oral solution.
研究壳聚糖季铵盐（HACC）对止嗽定喘口服液水提液的纯化效果。
采用改性壳聚糖季铵盐对止嗽定喘口服液水提液进行絮凝，以浊度及麻黄碱和甘草酸的保留率为指标，考察絮凝剂用量、混悬温度、搅拌速度和时间对絮凝效果的影响。通过正交试验设计得出最佳工艺条件。
最佳工艺条件为：絮凝温度30℃，HACC用量0.4 g·L⁻¹，快速搅拌速度500 r·min⁻¹、时间1 min，慢速搅拌速度50 r·min⁻¹、时间2.4～10 min。在此条件下，麻黄碱保留率为97.6%，30天后浊度分别为1.1 NTU和2.8 NTU。
HACC可用于止嗽定喘口服液水提液的纯化。
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