Diabetes Center, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA.
Endocr Pract. 2012 Jul-Aug;18(4):456-63. doi: 10.4158/EP11309.OR.
To assess the effect of hospital admission on glycemic control in patients with diabetes up to 1 year after discharge.
We retrospectively studied 826 adults with diabetes admitted to a tertiary care medical center and with available hemoglobin A1c (A1C) values for 6 months before admission and 1 year after discharge. We compared them with 826 nonhospitalized adults with diabetes matched for age, sex, race, comorbidity, and baseline A1C level. We determined the change in A1C value relative to hospitalization and baseline A1C level by using multivariate random effects models for repeated measures. Logistic regression analysis was performed to determine predictors of achieving recommended A1C levels at 1 year.
Patients with baseline A1C levels ≥9% had an adjusted rate of change in A1C value of -0.10% per month (95% confidence interval [CI], -0.18 to -0.022; P=.012) during the course of 1 year, without significant differences between hospitalized and nonhospitalized patients in the mean rate of change. Hospitalized patients, however, were less likely to achieve an A1C goal of ≤7% at 1 year (odds ratio, 0.68; 95% CI, 0.55 to 0.86; P<.001) or an A1C of <8% at 1 year (odds ratio, 0.62; 95% CI, 0.48 to 0.81; P<.001) in comparison with the nonhospitalized patients.
Despite an overall trend toward improved glycemia over time, hospitalized patients with uncontrolled diabetes were less likely to achieve glycemic targets at 1 year in comparison with matched nonhospitalized patients. These results suggest a missed opportunity to improve long-term glycemic control in hospitalized patients with diabetes.
评估患者出院后 1 年内住院对糖尿病患者血糖控制的影响。
我们回顾性研究了 826 例入住三级医疗中心的成年糖尿病患者,并在入院前 6 个月和出院后 1 年获得了血红蛋白 A1c(A1C)值。我们将其与 826 例年龄、性别、种族、合并症和基线 A1C 水平相匹配的未住院的成年糖尿病患者进行比较。我们使用多元随机效应模型对重复测量进行分析,确定相对于住院和基线 A1C 水平的 A1C 值变化。进行逻辑回归分析以确定在 1 年内达到推荐 A1C 水平的预测因素。
基线 A1C 水平≥9%的患者在 1 年内 A1C 值的变化率为每月-0.10%(95%置信区间为-0.18 至-0.022;P=.012),住院和未住院患者的平均变化率之间无显著差异。然而,与未住院患者相比,住院患者在 1 年内达到 A1C 目标≤7%(优势比,0.68;95%置信区间,0.55 至 0.86;P<.001)或 A1C <8%的可能性较小(优势比,0.62;95%置信区间,0.48 至 0.81;P<.001)。
尽管随着时间的推移血糖总体呈改善趋势,但与匹配的未住院患者相比,血糖控制不佳的住院糖尿病患者在 1 年内达到血糖目标的可能性较小。这些结果表明,住院的糖尿病患者有机会改善长期血糖控制。