Mother-Infant Department, Institute of Obstetrics and Gynaecology, University of Modena and Reggio Emilia, Modena, Italy.
BJOG. 2012 Sep;119(10):1171-9. doi: 10.1111/j.1471-0528.2012.03412.x. Epub 2012 Jul 17.
To elaborate a nomogram based on markers of ovarian reserve for the calculation of the appropriate starting dose of follicle-stimulating hormone (FSH).
Cohort study of infertile women.
In vitro fertilisation (IVF) unit, University Hospital of Modena, Italy.
Women aged 18-40 years (n = 346) and undergoing their first IVF cycle.
Serum FSH and anti-Müllerian hormone (AMH) measurement.
Development of a model for the prediction of ovarian response to FSH.
A model based on age, AMH and FSH was able to accurately predict the ovarian sensitivity and accounted for 30% of the variability of ovarian response to FSH. An FSH dosage nomogram was constructed and overall it predicts a starting FSH dose <225 IU in 55.1 and 25.9% of women younger and older than 35 years, respectively.
In the present study we clearly demonstrated that the daily FSH dose may be calculated on the basis of a woman's age and two markers of ovarian reserve, namely AMH and FSH, with the first two vari;s (age and AMH) being the most significant predictors. The nomogram we developed seems easily applicable for clinicians during their daily clinical practice.
基于卵巢储备标志物制定卵泡刺激素（FSH）起始剂量计算的列线图。
不孕女性的队列研究。
意大利摩德纳大学医院体外受精（IVF）中心。
年龄 18-40 岁的女性（n=346），正在进行首次 IVF 周期。
血清 FSH 和抗苗勒管激素（AMH）测量。
建立预测 FSH 卵巢反应的模型。
基于年龄、AMH 和 FSH 的模型能够准确预测卵巢对 FSH 的敏感性，解释了 FSH 卵巢反应变异性的 30%。构建了一个 FSH 剂量列线图，总体上它预测年龄小于 35 岁和大于 35 岁的女性起始 FSH 剂量<225IU 的比例分别为 55.1%和 25.9%。
在本研究中，我们明确表明，女性的每日 FSH 剂量可以基于年龄和两个卵巢储备标志物（即 AMH 和 FSH）进行计算，前两个变量（年龄和 AMH）是最重要的预测因素。我们开发的列线图似乎在临床医生的日常临床实践中易于应用。
