Management of malignant gliomas and primary CNS lymphoma: standard of care and future directions.

PURPOSE OF REVIEW

This article review the current standard of care of astrocytic gliomas and primary CNS lymphoma and discusses promising new therapeutic targets.

RECENT FINDINGS

Standard treatment modalities for primary malignant brain tumors include resection, radiation, local or systemic chemotherapy, and, most recently, antiangiogenic agents. However, these tumors often have a rapid course, and patients usually die within a few years of diagnosis. Improved surgical techniques and radiation and chemotherapy can prolong survival while maintaining quality of life, but these therapies remain inadequate.

SUMMARY

The care of patients with malignant brain tumors is challenging. A better understanding of the pathogenesis of primary malignant brain tumors and the elucidation of aberrant molecular pathways are leading to novel treatment strategies and the ability to identify patients who may benefit from specific treatments.