Prinz A
Institut für Geschichte der Medizin, Universität Wien.
Wien Klin Wochenschr. 1990 Dec 21;102(24):721-3.
The cardiac side effects of chinchona bark were discovered very soon after its introduction to the materia medica of academic medicine towards the end of the 17th century (Georg Ernst Stahl, 1660-1734). Therapeutically these effects were utilized sporadically as early as in the first half of the 18th century (Gerhard van Swieten, 1700-1772; John Wall, 1708-1776; William Saunders, 1743-1817). Purified quinine became a standard component of cardiac therapy in the 2nd half of the 19th century (Ludwig Traube, 1818-1876; Johann Oppolzer, 1808-1871; Karel Frederik Wenckebach, 1864-1940). In 1918 quinidine was introduced by Walter Frey (1884-1972) as the common alkaloid of chinchona bark and is still used in rhythmology today.
金鸡纳树皮的心脏副作用在17世纪末被引入学术医学药物学后不久就被发现了（格奥尔格·恩斯特·施塔尔，1660 - 1734）。早在18世纪上半叶，这些作用就被偶尔用于治疗（格哈德·范·斯维滕，1700 - 1772；约翰·沃尔，1708 - 1776；威廉·桑德斯，1743 - 1817）。纯化的奎宁在19世纪下半叶成为心脏治疗的标准成分（路德维希·特劳贝，1818 - 1876；约翰·奥波策尔，1808 - 1871；卡雷尔·弗雷德里克·温克巴赫，1864 - 1940）。1918年，沃尔特·弗雷（1884 - 1972）将奎尼丁作为金鸡纳树皮的常见生物碱引入，至今仍用于心律失常学。
