OVO Clinic, 8000 boulevard Décarie, Montréal, Québec, Canada.
Reprod Biomed Online. 2012 Sep;25(3):242-7. doi: 10.1016/j.rbmo.2012.06.003. Epub 2012 Jun 19.
A retrospective cohort study was performed to evaluate the outcome of modified natural IVF-intracytoplasmic sperm injection (mnIVF-ICSI) cycles to compare 81 mnIVF-ICSI first cycles using ejaculated spermatozoa with 44 mnIVF-ICSI first cycles using surgically retrieved spermatozoa. There were no differences between the two groups in terms of number of oocytes retrieved, oocyte maturity or female age. However, male age was significantly higher in the surgically retrieved compared with the ejaculated group (41.5 versus 36.5 years, P=0.001). There were no significant differences in fertilization rate or cleavage rate between the ejaculated and the surgically retrieved groups; however the prevalence of embryo transfer was higher in the surgically retrieved group (65.9% versus 45.7%, P=0.03). Only single-embryo transfer was performed. Biochemical (34.5% versus 37.8%) and clinical (31.0% versus 35.1%) pregnancy rates per embryo transfer were similar between the ejaculated and the surgically retrieved groups. The data suggest that mnIVF-ICSI is an alternative treatment option in couples with severe male factor infertility where surgical sperm retrieval is required. The aim of the present study was to evaluate and compare the outcomes of modified natural IVF-intracytoplasmic sperm injection (mnIVF-ICSI) with surgically retrieved spermatozoa (in male partners with obstructive azoospermia) and ejaculated spermatozoa (in couples with mild-to-moderate male factor). Eighty-one mnIVF-ICSI first cycles using ejaculated spermatozoa were compared with forty-four mnIVF-ICSI first cycles using surgically retrieved spermatozoa. There were no differences between the two groups in terms of number of oocytes retrieved, oocyte maturity or female age. However, male age was significantly higher in the surgically retrieved compared with the ejaculated group. There were no significant differences in fertilization rate, or cleavage rate between the two groups; however, there were more patients having embryo transfers in the surgically retrieved group. Only single-embryo transfer was performed. Biochemical and clinical pregnancy rates per embryo transfer were similar between both groups. The data suggest that mnIVF-ICSI is an alternative treatment option in couples with severe male factor infertility where surgical sperm retrieval is required.
一项回顾性队列研究评估了改良自然体外受精-胞浆内单精子注射（mnIVF-ICSI）周期的结局，比较了 81 例使用射出精液的 mnIVF-ICSI 首次周期和 44 例使用手术获取精子的 mnIVF-ICSI 首次周期。在获取的卵母细胞数量、卵母细胞成熟度或女性年龄方面，两组间无差异。然而，手术组的男性年龄明显高于射出组（41.5 岁比 36.5 岁，P=0.001）。射出组和手术组的受精率或卵裂率无显著差异；然而，手术组胚胎移植的发生率较高（65.9%比 45.7%，P=0.03）。仅进行了单胚胎移植。生化妊娠率（34.5%比 37.8%）和临床妊娠率（31.0%比 35.1%）在射出组和手术组间相似。
这些数据表明，在需要手术获取精子的严重男性因素不育夫妇中，mnIVF-ICSI 是一种替代治疗选择。本研究的目的是评估和比较改良自然体外受精-胞浆内单精子注射（mnIVF-ICSI）与手术获取精子（在梗阻性无精子症的男性伴侣中）和射出精子（在轻中度男性因素的夫妇中）的结局。比较了 81 例使用射出精子的 mnIVF-ICSI 首次周期和 44 例使用手术获取精子的 mnIVF-ICSI 首次周期。在获取的卵母细胞数量、卵母细胞成熟度或女性年龄方面，两组间无差异。然而，手术组的男性年龄明显高于射出组。两组间的受精率或卵裂率无显著差异；然而，手术组进行胚胎移植的患者较多。仅进行了单胚胎移植。生化妊娠率和临床妊娠率在两组间相似。这些数据表明，mnIVF-ICSI 是一种替代治疗选择，适用于需要手术获取精子的严重男性因素不育夫妇。
