长效奥曲肽治疗纳尔逊综合征和库欣病后的激素分泌和生活质量：一个简短系列和更新。

Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update.

机构信息

1Endocrine Research Department, Instituto de Investigaciones Médicas Alfredo Lanari, University of Buenos Aires; 2IDIM-CONICET and 3Salivary Glands Laboratory, University of Buenos Aires, Buenos Aires, Argentina.

出版信息

Am J Ther. 2014 Jul-Aug;21(4):e110-6. doi: 10.1097/MJT.0b013e318255bc07.

DOI:10.1097/MJT.0b013e318255bc07

PMID:22820717

Abstract

Clinical management of persistent adrenocorticotropin hormone (ACTH) excess in Nelson syndrome (NS) and Cushing disease (CD) remains a challenge. Somatostatin and its analogs as octreotide decrease ACTH secretion through somatostatin receptors of pituitary cells. To our knowledge, there are no reports on the effect of long-acting repeatable octreotide (oct-lar) on hormonal secretion and quality of life in patients with NS and CD who failed conventional therapy. Herein, we describe the effects of treatment with oct-lar (20 mg/month intramurally) in 1 woman with NS and 2 women with persistent CD. Oct-lar therapy reduced ACTH secretion and improved the quality of life in NS patient. By contrast, in CD patients, it failed to control ACTH and cortisol secretion, and the quality of life remained unchanged.

摘要

纳尔逊综合征（NS）和库欣病（CD）患者的促肾上腺皮质激素（ACTH）持续过多的临床治疗仍然是一个挑战。生长抑素及其类似物奥曲肽通过垂体细胞的生长抑素受体减少 ACTH 的分泌。据我们所知，尚无关于长效可重复奥曲肽（oct-lar）对常规治疗失败的 NS 和 CD 患者的激素分泌和生活质量影响的报道。在此，我们描述了奥曲肽（每月 20 毫克肌内注射）治疗 1 例 NS 患者和 2 例持续性 CD 患者的效果。奥曲肽治疗降低了 NS 患者的 ACTH 分泌并改善了生活质量。相比之下，在 CD 患者中，奥曲肽未能控制 ACTH 和皮质醇的分泌，生活质量保持不变。