Dubuisson L, Bedin C, Boussarie L, Grenier N, Boudat A M, Bioulac-Sage P, Balabaud C
Laboratoire des Interactions Cellulaires, Université de Bordeaux II, France.
J Submicrosc Cytol Pathol. 1990 Oct;22(4):577-86.
Sinusoids and sinusoidal cells were examined by light and electron microscopy, using a rat model of postsinusoidal hypertension. One month after partial ligation of the vena cava (PLVC) above the hepatic veins, subcapsular hemorrhagic areas were visible with proliferation of hepatic veins; in non hemorrhagic areas, sinusoidal congestion was found. Postsinusoidal hypertension led to a significant increase in sinusoidal volume and to major abnormalities of the endothelium such as endothelial processes and pouches with numerous diaphragmed fenestrae; some red blood cells could be seen in these pouches. Endothelial cells sent out processes in between hepatocytes. Complete and incomplete pseudo-neolumens were found near sinusoids. Numerous Kupffer cells were located either in the sinusoidal barrier or infiltrating the Disse space close to extravasated red blood cells and perisinusoidal cell processes. 18 months after PLVC, lesions were much the same except for the presence of red blood cells in the Disse space.
使用肝后性高血压大鼠模型，通过光学显微镜和电子显微镜对肝血窦和肝血窦细胞进行了检查。在肝静脉上方部分结扎腔静脉（PLVC）后1个月，可见肝包膜下出血区域伴肝静脉增生；在非出血区域，发现肝血窦充血。肝后性高血压导致肝血窦容积显著增加，并使内皮细胞出现严重异常，如内皮突起和带有许多有隔膜窗孔的囊袋；在这些囊袋中可见一些红细胞。内皮细胞在肝细胞之间发出突起。在肝血窦附近发现了完整和不完整的假管腔。大量库普弗细胞位于肝血窦屏障处，或浸润至靠近外渗红细胞和肝血窦周细胞突起的狄氏间隙。PLVC后18个月，除狄氏间隙存在红细胞外，病变大致相同。
