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慢性乙型肝炎患者停用核苷类似物后导致的急性肝衰竭:两例报告

Acute liver failure resulting from discontinuation of nucleoside analogues in chronic hepatitis B patients: a report of two cases.

作者信息

Wang Junshuai, Wang Minxin, Huang Yuancheng

机构信息

Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Scand J Infect Dis. 2013 Feb;45(2):158-60. doi: 10.3109/00365548.2012.704152. Epub 2012 Jul 25.

Abstract

Lamivudine, adefovir, telbivudine, and entecavir are nucleoside analogues that can inhibit hepatitis B virus replication and are licensed in China by the Food and Drug Administration. This study presents the cases of 2 patients who were chronically infected with HBV and suffered hepatic failure resulting from withdrawal of telbivudine and adefovir, respectively.

摘要

拉米夫定、阿德福韦、替比夫定和恩替卡韦都是核苷类似物,它们能够抑制乙型肝炎病毒复制,且已在中国获得食品药品监督管理局的许可。本研究报告了2例慢性乙型肝炎病毒感染患者的病例,这2例患者分别因停用替比夫定和阿德福韦而导致肝衰竭。

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