Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
Acta Paediatr. 2012 Nov;101(11):1151-5. doi: 10.1111/j.1651-2227.2012.02796.x. Epub 2012 Sep 11.
In a recent Swedish study, comparing data from the Swedish Cancer Register with the Medical Birth Register including data on IVF, an increased risk of Langerhans cell histiocytosis (LCH) was found in children born 1982-2005 after IVF. Here, we aimed to verify the LCH diagnoses and examine whether any special forms of the disease were overrepresented in this population.
Medical records for all children with LCH conceived by IVF were acquired and the diagnosis confirmed or discarded. Disease characteristics were compared with data from children diagnosed with LCH 1992-2001 in the Stockholm County.
We verified LCH in seven children born after IVF, all born prior to 2002. These children did not have milder disease forms. The odds ratio (OR) to develop LCH for the whole group born after IVF was 3.2 [95% confidence interval (CI), 1.4-7.3] and for children born before 2002, 5.2 [95% CI, 2.3-11.9], compared with children in Stockholm County 1992-2001.
LCH was overrepresented in children born after IVF prior to 2002. Affected children did not have milder disease forms. These findings may be valuable to understand LCH aetiology. Additional studies on a putative correlation between IVF and LCH in the offspring are encouraged.
在最近一项瑞典研究中，通过比较瑞典癌症登记处的数据与包括 IVF 数据的医疗出生登记处的数据，发现 1982 年至 2005 年期间通过 IVF 出生的儿童患朗格汉斯细胞组织细胞增生症（LCH）的风险增加。在此，我们旨在验证 LCH 诊断，并检查该人群中是否存在任何特殊形式的疾病。
获取所有通过 IVF 受孕的 LCH 患儿的医疗记录，并确认或排除诊断。将疾病特征与 1992-2001 年斯德哥尔摩县诊断为 LCH 的儿童数据进行比较。
我们验证了 7 例通过 IVF 出生的 LCH 患儿，均在 2002 年之前出生。这些患儿没有更轻微的疾病形式。整个 IVF 后出生组发生 LCH 的比值比（OR）为 3.2（95%置信区间[CI]，1.4-7.3），而 2002 年之前出生的儿童则为 5.2（95%CI，2.3-11.9），与 1992-2001 年斯德哥尔摩县的儿童相比。
在 2002 年之前通过 IVF 出生的儿童中，LCH 发病率较高。受影响的患儿没有更轻微的疾病形式。这些发现可能有助于理解 LCH 的病因。鼓励对 IVF 与后代 LCH 之间可能存在的相关性进行更多的研究。
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