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双侧丘脑底核深部脑刺激对帕金森病弯腰驼背的长期益处。

Long-term benefit of bilateral subthalamic deep brain stimulation on camptocormia in Parkinson's disease.

作者信息

Lyons Mark, Boucher Orland, Patel Naresh, Birch Barry, Evidente Virgilio

机构信息

Mayo Clinic Arizona, Department of Neurological Surgery, Phoenix/AZ, USA.

出版信息

Turk Neurosurg. 2012;22(4):489-92. doi: 10.5137/1019-5149.JTN.3857-10.0.

Abstract

We report the case of a 63-year-old female with a long history of severe Parkinson's disease (PD) and subsequent onset of debilitating camptocormia who underwent successful bilateral subthalamic nucleus deep brain stimulation surgery (STN DBS). The literature and previous reports are reviewed. The patient history and details of the surgical procedure are reported including the implantable pulse generator (IPG) settings and response to stimulation. The results of her PD symptom and camptocormia improvements are discussed. Five year postoperatively, the patient has enjoyed good results for both her PD symptoms as well as significant and sustained improvement in her thoracolumbar flexion deformity. She remains on minimal medications and no longer requires any assistive devices for ambulation. Comparison and contrast of the current world literature on DBS for camptocormia is reviewed. We discuss the current targets used for DBS in the setting of camptocormia in the cases reported, both PD associated and not associated. The optimal target has yet to be defined and further work on appropriate patient selection is needed.

摘要

我们报告了一例63岁女性患者,该患者患有严重帕金森病(PD)病史已久,随后出现使人衰弱的脊柱前凸,并接受了成功的双侧丘脑底核深部脑刺激手术(STN DBS)。我们回顾了相关文献和既往报告。报告了患者病史及手术过程细节,包括植入式脉冲发生器(IPG)设置及刺激反应。讨论了其帕金森病症状及脊柱前凸改善情况。术后五年,患者的帕金森病症状以及胸腰椎屈曲畸形均得到显著且持续的改善。她目前服用极少的药物,行走时不再需要任何辅助装置。我们回顾了当前世界范围内关于DBS治疗脊柱前凸的文献比较与对比。我们讨论了在已报道病例中,与帕金森病相关或无关情况下,用于治疗脊柱前凸的DBS当前靶点。最佳靶点尚未明确,需要进一步开展关于合适患者选择的研究。

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