Gadó Klára, Domján Gyula
Semmelweis Egyetem, Általános Orvostudományi Kar I. Belgyógyászati Klinika Budapest Korányi S. u. 2/A 1083.
Orv Hetil. 2012 Aug 5;153(31):1207-18. doi: 10.1556/OH.2012.29425.
Antiphospholipid syndrome is characterized by arterial and venous thromboembolic events and persistent laboratory evidence of antiphospholipid antibodies. Obstetric complications such as recurrent miscarriage, early delivery, oligohydramnios, prematurity, intrauterine growth restriction, fetal distress, fetal or neonatal thrombosis, pre-eclampsia/eclampsia, and HELLP syndrome are also hallmarks of antiphospholipid syndrome. This syndrome is one of the diseases associated with the most severe thrombotic risk. Changes in the hemostatic system during normal pregnancy also result in a hypercoagulable state resulting in elevated thrombotic risk. Thromboembolic events are responsible of the vast majority of maternal and fetal deaths. Administration of appropriate thromboprophylaxis helps prevent thromboembolic complications during pregnancy in women with antiphospholipid syndrome and also give birth to healthy children. It is important to centralize the medication and management of these patients. It helps in the thoughtful care of these pregnant women encountering serious problems.
抗磷脂综合征的特征是动脉和静脉血栓栓塞事件以及抗磷脂抗体的持续实验室证据。复发性流产、早产、羊水过少、早产、宫内生长受限、胎儿窘迫、胎儿或新生儿血栓形成、先兆子痫/子痫以及HELLP综合征等产科并发症也是抗磷脂综合征的标志。该综合征是与最严重血栓形成风险相关的疾病之一。正常妊娠期间止血系统的变化也会导致高凝状态，从而增加血栓形成风险。血栓栓塞事件是导致绝大多数孕产妇和胎儿死亡的原因。给予适当的血栓预防有助于预防抗磷脂综合征女性孕期的血栓栓塞并发症，并生出健康的孩子。集中管理这些患者的用药和治疗很重要。这有助于对这些遇到严重问题的孕妇进行周到的护理。
