Yu Hee Joon, Kang I-Seok, Lee Munhyang, Kim Keon-Ha, Lee Jeehun
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-Ro, Seoul 135-710, Korea.
Childs Nerv Syst. 2012 Nov;28(11):1837-41. doi: 10.1007/s00381-012-1869-7. Epub 2012 Jul 31.
Diagnosis of arterial ischemic stroke in pediatric patients is often delayed due to the uncertainty and variability of clinical symptoms. Early diagnosis of arterial ischemic stroke can bring a favorable prognosis with prompt thrombolytic therapy or stent insertion, via transfemoral cerebral arteriogram. Acute thrombolytic therapy is rarely attempted in children because of the delayed diagnosis.
We report a case of a 4-year-old girl with complex heart disease who was presented with arterial ischemic stroke at the right distal internal carotid artery and successfully treated by stent insertion in which repeated thrombolysis or ballooning had failed.
Left hemiparesis was nearly recovered 6 days after the stent insertion. The mean flow velocity of the right middle cerebral artery has slightly improved compared to that of the initial study. She has been followed-up for 6 months in the outpatient clinic without neurologic sequelae.
This case suggests that intracranial stent insertion may be a safe and an effective modality in young children, when the thrombolytic therapy or ballooning is inapplicable. Additionally, transcranial Doppler ultrasonography is useful to monitor the cerebral blood flow after stent insertion in children.
由于临床症状的不确定性和变异性,小儿患者的动脉缺血性卒中诊断常常延迟。早期诊断动脉缺血性卒中,通过经股脑动脉造影,及时进行溶栓治疗或支架植入可带来良好预后。由于诊断延迟,儿童很少尝试急性溶栓治疗。
我们报告一例4岁患有复杂心脏病的女孩,其右颈内动脉远端发生动脉缺血性卒中,在反复溶栓或球囊扩张失败后成功接受了支架植入治疗。
支架植入6天后左侧偏瘫几乎恢复。与初始检查相比,右侧大脑中动脉的平均血流速度略有改善。她在门诊随访6个月,无神经后遗症。
该病例表明,当溶栓治疗或球囊扩张不适用时,颅内支架植入对幼儿可能是一种安全有效的治疗方式。此外,经颅多普勒超声检查有助于监测儿童支架植入后的脑血流情况。