Coseo N M, Saldua N, Harrop J
Naval Medical Center, San Diego, CA, USA.
J Neurosurg Sci. 2012 Sep;56(3):203-7.
Use of biologic graft extenders in spinal fusions is increasing. Multiple allograft alternatives exist to the "gold-standard" autologous bone grafting. The ideal graft extender is osteoconductive, osteoinductive and has osteogenic potential. While the ideal graft extender has yet to be found, available bone graft extenders have varying degrees of predominantly osteoconductive and osteoinductive properties. This review will provide an update on available graft extenders including bone morphogenetic proteins, mesenchymal stem cells, and demineralized bone matrix. The goal is to provide a review of the current use in spinal fusions and future directions in biologics for spinal fusion.
生物性移植物增强剂在脊柱融合术中的应用正在增加。除了“金标准”自体骨移植外，还有多种同种异体移植替代物。理想的移植物增强剂应具有骨传导性、骨诱导性并有成骨潜力。虽然尚未找到理想的移植物增强剂，但现有的骨移植物增强剂具有不同程度的主要为骨传导性和骨诱导性的特性。本综述将介绍包括骨形态发生蛋白、间充质干细胞和脱矿骨基质在内的现有移植物增强剂的最新情况。目的是对脊柱融合术中这些生物制剂的当前应用及脊柱融合生物制剂的未来发展方向进行综述。
